What is 3-Amino-pyridine-2-carboxylic acid amide CAS 50608-99-6
3-Amino-pyridine-2-carboxylic acid amide, also known as 2-carbamoyl-3-aminopyridine, is an important chemical intermediate used in the synthesis of various pharmaceuticals and agrochemicals. Its chemical formula is C6H7N3O2 and its CAS number is 50608-99-6. In this article, we will discuss the properties, synthesis, and applications of 3-amino-pyridine-2-carboxylic acid amide.
3-Amino-pyridine-2-carboxylic acid amide Properties and Synthesis
3-Amino-pyridine-2-carboxylic acid amide is a white to off-white crystalline powder with a melting point of 238-240°C. It is soluble in water, methanol, and ethanol. The synthesis of 3-amino-pyridine-2-carboxylic acid amide involves the reaction of 2-chloro-3-nitropyridine with ammonia followed by reduction with hydrogen gas or a reducing agent such as iron powder or sodium borohydride. The yield of the reaction is typically around 60-70%.
3-Amino-pyridine-2-carboxylic acid amide Applications
3-Amino-pyridine-2-carboxylic acid amide is a versatile intermediate used in the synthesis of various pharmaceuticals and agrochemicals. One of its major applications is in the synthesis of the anti-inflammatory drug, meloxicam. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation associated with osteoarthritis and rheumatoid arthritis. Other applications of 3-amino-pyridine-2-carboxylic acid amide include the synthesis of fungicides, herbicides, and insecticides.
3-Amino-pyridine-2-carboxylic acid amide Conclusion
3-Amino-pyridine-2-carboxylic acid amide is an important chemical intermediate used in the synthesis of various pharmaceuticals and agrochemicals. Its properties and synthesis have been discussed in this article, along with its major application in the synthesis of the anti-inflammatory drug, meloxicam. With its versatile applications, 3-amino-pyridine-2-carboxylic acid amide is a valuable compound in the field of chemical synthesis.
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