2-Deoxy-D-glucose, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Appearance: White powder
- Assay: 99%min
- Packaging: 25kg/Fiber drum.
- Sample: Available
2-Deoxy-D-glucose: The Complete Guide
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Quality Control of 2-Deoxy-D-glucose
Quality Control & MSDS
Packing of Bretazenil
Description of 2-Deoxy-D-glucose
2-Deoxy-D-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such, it acts to competitively inhibit the production of glucose-6-PO4 from glucose at the phosphoglucoisomerase level. In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate intracellularly (with exception of liver and kidney); thus, labeled forms of 2-deoxyglucose serve as a good marker for tissue glucose uptake and hexokinase activity. Many cancers have elevated glucose uptake and hexokinase levels. 2-Deoxyglucose labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where distribution is assessed by tissue-slicing followed by autoradiography, sometimes in tandem with either conventional or electron microscopy.
2-DG is uptaken by the glucose transporters of the cell. Therefore, cells with higher glucose uptake, for example tumor cells, have also a higher uptake of 2-DG. Since 2-DG hampers cell growth, its use as a tumor therapeutic has been suggested, and in fact, 2-DG is in clinical trials A recent clinical trial showed 2-DG can be tolerated at a dose of 63mg/kg/day, however the observed cardiac side-effects (prolongation of the Q-T interval) at this dose and the fact that a majority of patients’ (66%) cancer progressed casts doubt on the feasibility of this reagent for further clinical use. However, it is not completely clear how 2-DG inhibits cell growth. The fact that glycolysis is inhibited by 2-DG, seems not to be sufficient to explain why 2-DG treated cells stop growing ; Clinicians have noted that 2-DG is metabolised in the pentose phosphate pathway in red blood cells at least, although the significance of this for other cell types and for cancer treatment in general is unclear.
Work on the ketogenic diet as a treatment for epilepsy have investigated the role of glycolysis in the disease. 2-Deoxyglucose has been proposed by Garriga-Canut et al. as a mimic for the ketogenic diet, and shows great promise as a new anti-epileptic drug. The authors suggest that 2-DG works, in part, by increasing the expression of Brain-derived neurotrophic factor (BDNF), Nerve growth factor (NGF), Arc (protein) (ARC), and Basic fibroblast growth factor (FGF2). Such uses are complicated by the fact that 2-deoxyglucose does have some toxicity.
By combining the sugar 2-Deoxy-D-glucose (2-DG) with fenofibrate, a compound that has been safely used in humans for more than 40 years to lower cholesterol and triglycerides, the entire tumor could effectively be targeted without the use of toxic chemotherapy.
2-DG has been used as a targeted optical imaging agent for fluorescent in vivo imaging. In clinical medical imaging (PET scanning), fluorodeoxyglucose is used, where one of the 2-hydrogens of 2-deoxy-D-glucose is replaced with the positron-emitting isotope fluorine-18, which emits paired gamma rays, allowing distribution of the tracer to be imaged by external gamma camera(s). This is increasingly done in tandem with a CT function which is part of the same PET/CT machine, to allow better localization of small-volume tissue glucose-uptake differences.
Basic Info of Bretazenil
Appearance & Physical State
411ºC at 760 mmHg
Stable under normal temperatures and pressures.
1.8E-08mmHg at 25°C
What is 2-Deoxy-D-glucose?
Part I: Introduction
This new coronary epidemic has gradually made people more aware about protection and disinfection, all countries are looking for better disinfectants and drugs to deal with this epidemic, one of the products is 2-deoxy-D-glucose which is very effective for disinfection in this epidemic, do you know about 2-deoxy-D-glucose?
The official answer: 2-Deoxy-D-Glucose is an anti-metabolic substance of D-Glucose, which has the effect of interfering with the synthesis of virus-specific glycoproteins, inhibiting the proliferation of herpes mono virus, RAN and DNA enveloped viruses, and cancer cells. Currently, anti-viral and anti-cancer drugs prepared from 2-deoxy-D-glucose have been clinically applied in herpes mono virus and cancer treatment, and pharmaceutical and anti-aging cosmetics prepared from 2-deoxy-D-glucose have also been marketed.
Where are the application areas of 2-deoxy-D-glucose?
Part II: In-depth development
Deoxy-D-glucose is a natural antimetabolite antibiotic with a variety of physiological and pharmacological effects, including inhibition of viral infections, yeast fermentation, pathogens, and tumor cell growth. It is used for the prevention of viral and pathogenic infections and can prevent infectious diseases caused by pathogens such as HSV, HIV, influenza virus, herpes, etc. It is mainly used for the prevention and treatment of various viral diseases and immunosuppressive diseases in livestock and poultry, and also as an auxiliary treatment for bacterial and mycoplasma infections. It has wide application prospects in the pharmaceutical and cosmetic industries. Yongzeng Chemical, currently used mainly for poultry and veterinary medicine in China.
It is a natural antimetabolite antibiotic with the ability to inhibit viral infections, yeast fermentation, pathogenic bacteria, and tumor cell growth.
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