2-Deoxy-D-glucose CAS# 154-17-6
2-Deoxy-D-glucose, Promotion Season Now in Store and Free Sample for Testing with Factory Price
- Appearance: White powder.
- Assay: 99.31%min.
- Packaging: 1kg/Foil bag.
- Sample: Available.
2-Deoxy-D-glucose: The Complete Guide
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Quality Control & MSDS
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Description of 2-Deoxy-D-glucose
2-Deoxy-D-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such, it acts to competitively inhibit the production of glucose-6-PO4 from glucose at the phosphoglucoisomerase level. In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate intracellularly (with exception of liver and kidney); thus, labeled forms of 2-deoxyglucose serve as a good marker for tissue glucose uptake and hexokinase activity. Many cancers have elevated glucose uptake and hexokinase levels. 2-Deoxyglucose labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where distribution is assessed by tissue-slicing followed by autoradiography, sometimes in tandem with either conventional or electron microscopy.
2-DG is uptaken by the glucose transporters of the cell. Therefore, cells with higher glucose uptake, for example tumor cells, have also a higher uptake of 2-DG. Since 2-DG hampers cell growth, its use as a tumor therapeutic has been suggested, and in fact, 2-DG is in clinical trials A recent clinical trial showed 2-DG can be tolerated at a dose of 63mg/kg/day, however the observed cardiac side-effects (prolongation of the Q-T interval) at this dose and the fact that a majority of patients’ (66%) cancer progressed casts doubt on the feasibility of this reagent for further clinical use. However, it is not completely clear how 2-DG inhibits cell growth. The fact that glycolysis is inhibited by 2-DG, seems not to be sufficient to explain why 2-DG treated cells stop growing ; Clinicians have noted that 2-DG is metabolised in the pentose phosphate pathway in red blood cells at least, although the significance of this for other cell types and for cancer treatment in general is unclear.
Work on the ketogenic diet as a treatment for epilepsy have investigated the role of glycolysis in the disease. 2-Deoxyglucose has been proposed by Garriga-Canut et al. as a mimic for the ketogenic diet, and shows great promise as a new anti-epileptic drug. The authors suggest that 2-DG works, in part, by increasing the expression of Brain-derived neurotrophic factor (BDNF), Nerve growth factor (NGF), Arc (protein) (ARC), and Basic fibroblast growth factor (FGF2). Such uses are complicated by the fact that 2-deoxyglucose does have some toxicity.
By combining the sugar 2-Deoxy-D-glucose (2-DG) with fenofibrate, a compound that has been safely used in humans for more than 40 years to lower cholesterol and triglycerides, the entire tumor could effectively be targeted without the use of toxic chemotherapy.
2-DG has been used as a targeted optical imaging agent for fluorescent in vivo imaging. In clinical medical imaging (PET scanning), fluorodeoxyglucose is used, where one of the 2-hydrogens of 2-deoxy-D-glucose is replaced with the positron-emitting isotope fluorine-18, which emits paired gamma rays, allowing distribution of the tracer to be imaged by external gamma camera(s). This is increasingly done in tandem with a CT function which is part of the same PET/CT machine, to allow better localization of small-volume tissue glucose-uptake differences.
Basic Info of 2-Deoxy-D-glucose
Appearance & Physical State
411ºC at 760 mmHg
Stable under normal temperatures and pressures.
1.8E-08mmHg at 25°C
What is 2-Deoxy-D-glucose?
With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is 2-Deoxy-D-glucose which has developed particularly rapidly in recent years. Do you know about 2-Deoxy-D-glucose?
The official answer:2-Deoxy-D-glucose is a chemical with the molecular formula C6H12O5.
What’s the application of 2-Deoxy-D-glucose?
2-Deoxy-D-glucose is an inhibitor of glucose metabolism and has been reported to reverse lupus symptoms in mice together with metformin (M258815). 2-Deoxy-D-glucose is a derivative of D-glucose, which is an antimetabolite and an important component of orthomyxovirus, paramyxovirus, and herpesvirus capsids, and can interfere with the synthesis of virus-specific glycoproteins and effectively inhibits the proliferation of herpes mono virus, RNA and DNA enveloped virus, and breast cancer cells, etc. Anti-viral and anti-cancer drugs made from 2-deoxy-D-glucose in Chemicalbook have been used in clinical treatment studies of herpes mono virus, influenza, AIDS, and cancer; anti-aging cosmetics and pharmaceuticals made from 2-deoxy-D-glucose have also been marketed. Therefore, as a drug for cancer, viral diseases, and anti-aging, 2-deoxy-D-glucose has a wide application prospect and huge market demand. It is a natural antimetabolite antibiotic with various physiological and pharmacological effects such as inhibition of viral infection, yeast fermentation, germs, and tumor cell growth. It can be used for the prevention of viral and pathogenic bacterial infections, preventing infectious diseases caused by chemical book pathogens such as HSV, HIV, and influenza virus, and treating herpes, etc. It is mainly used for the prevention and treatment of various viral diseases and immunosuppressive diseases in livestock and poultry, and can also be used as an auxiliary treatment for bacterial and mycoplasma infections, and has a wide range of applications in the pharmaceutical and cosmetic industries. Cosmetics and other industries have a wide range of application prospects. Yongzeng Chemical, currently mainly used in poultry and veterinary medicine in China. 2-Deoxy-D-Glucose (2-DG) is a natural antimetabolite antibiotic, which can inhibit viral infection, yeast fermentation, pathogenic bacteria, and tumor cell growth, etc.
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