4-Dimethylaminopyridine CAS# 1122-58-3

4-Dimethylaminopyridine is a new type of highly efficient catalyst widely used in chemical synthesis in recent years. The resonance of the electron-donating dimethylamine with the parent ring (pyridine ring) on its structure can strongly activate the nucleophilic substitution of the nitrogen atom on the ring and significantly catalyze the acylation (phosphorylation, sulfonylation, carbonylation) reactions of high potential resistance and low reactivity of alcohols and amines, and its activity is about 104-6 times that of pyridine. It has high catalytic ability in various types of reactions such as acylation, alkylation, etherification, esterification, and ester exchange in organic synthesis, drug synthesis, pesticides, pharmaceuticals, dyes, fragrances, polymer chemistry, and analytical chemistry, and has an extremely obvious effect on improving yields. Its advantages are: the catalyst dosage is small, usually only 0.01-5% of the molarity of the reaction substrate can be, the acid produced by the reaction can be neutralized by organic or inorganic bases; mild reaction conditions, generally at room temperature can be carried out, saving energy; wide choice of solvent, in polar, non-polar organic solvents can be carried out; short reaction time, using pyridine for a long time, while the DMAP is a few minutes to complete the reaction, thus greatly improving labor productivity; high yield, such as pyridine almost does not react with the hydroxyl compounds with large spatial resistance, the use of DMAP yield up to 80-90%, which can improve the reaction yield and product quality and simplify the process; fewer side reactions, small odor, less waste; due to the excellent catalytic performance of DMAP, known as “super catalyst “It has become one of the most commonly used catalysts for organic synthesis workers.