4-Dimethylaminopyridine CAS# 1122-58-3

4-Dimethylaminopyridine, Promotion Season Now in Store and Free Sample for Testing with Factory Price
  • Appearance: White powder
  • Assay: 99. 0%min
  • Packaging: 25kg/ Cardboard drums
  • Sample: Available

Quality Control of 4-Dimethylaminopyridine

Chemical Structure
4-Dimethylaminopyridine CAS# 1122-58-3
Packing of 4-Dimethylaminopyridine

Description of 4-Dimethylaminopyridine

4-Dimethylaminopyridine (DMAP) is a derivative of pyridine with the chemical formula (CH3)2NC5H4N. This colourless solid is of interest because it is more basic than pyridine, owing to the resonance stabilisation from the NMe2 substituent.
Because of its basicity, DMAP is a useful nucleophilic catalyst for a variety of reactions such as esterifications with anhydrides, the Baylis-Hillman reaction, hydrosilylations, tritylation, the Steglich rearrangement, Staudinger synthesis of β-lactams and many more. Chiral DMAP analogues are used in kinetic resolution experiments of mainly secondary alcohols and Evans auxiliary type amides.

Basic Info of 4-Dimethylaminopyridine

Basic Info

Chemical Name



4-Dimethylaminopyrid;AURORA KA-6495;N-(4-Pyridyl)dimethylamine;4-Pyridinamine, N,N-dimethyl-;4-Dimethylaminepyridine;Expand



Molecular Formula


Molecular Weight






Safety Info



Hazard Class


Safety Statements


HS Code


WGK Germany


Packing Group



UN 1760/2811

Risk Statements

R24/25; R34

Hazard Codes


Hazard Declaration

H302; H311; H315; H319; H335; H351

Signal Word


Caution Statement

P280; P301 + P312 + P330; P302 + P352 + P312; P304 + P340 + P312; P305 + P351 + P338; P337 + P313


GHS06, GHS08



Appearance & Physical State

white to yellow crystalline powder


1.012 g/cm3

Boiling Point

162ºC (50 mmHg)

Melting Point


Flash Point


Refractive Index

n20/D 1.431

Water Solubility

76 g/L (25 ºC)


Stable. Incompatible with acids, oxidizing agents.

Storage Condition

Store in dark

Vapor Pressure

0.431mmHg at 25°C


Numbering system

MDL number


EINECS number


RTECS number


BRN number



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What is 4-Dimethylaminopyridine?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is 4-Dimethylaminopyridine which has developed particularly rapidly in recent years. Do you know about 4-Dimethylaminopyridine?


The official answer:4-Dimethylaminopyridine is a new high-efficiency catalyst widely used in chemical synthesis. 4-Dimethylaminopyridine is a new high-efficiency catalyst widely used in chemical synthesis in recent years, and the resonance of the electron-donating dimethylamine with the parent ring (pyridine ring) on its structure can strongly activate the nucleophilic substitution of the nitrogen atom on the ring, which significantly catalyzes the acylation (phosphorylation, sulfonylation, carbonylation) reaction of high potential resistance and low reactivity alcohols and amines, and its activity is about 104-6 times that of pyridine.

What’s the application of 4-Dimethylaminopyridine?

4-Dimethylaminopyridine is a new type of highly efficient catalyst widely used in chemical synthesis in recent years. The resonance of the electron-donating dimethylamine with the parent ring (pyridine ring) on its structure can strongly activate the nucleophilic substitution of the nitrogen atom on the ring and significantly catalyze the acylation (phosphorylation, sulfonylation, carbonylation) reactions of high potential resistance and low reactivity of alcohols and amines, and its activity is about 104-6 times that of pyridine. It has high catalytic ability in various types of reactions such as acylation, alkylation, etherification, esterification, and ester exchange in organic synthesis, drug synthesis, pesticides, pharmaceuticals, dyes, fragrances, polymer chemistry, and analytical chemistry, and has an extremely obvious effect on improving yields. Its advantages are: the catalyst dosage is small, usually only 0.01-5% of the molarity of the reaction substrate can be, the acid produced by the reaction can be neutralized by organic or inorganic bases; mild reaction conditions, generally at room temperature can be carried out, saving energy; wide choice of solvent, in polar, non-polar organic solvents can be carried out; short reaction time, using pyridine for a long time, while the DMAP is a few minutes to complete the reaction, thus greatly improving labor productivity; high yield, such as pyridine almost does not react with the hydroxyl compounds with large spatial resistance, the use of DMAP yield up to 80-90%, which can improve the reaction yield and product quality and simplify the process; fewer side reactions, small odor, less waste; due to the excellent catalytic performance of DMAP, known as “super catalyst “It has become one of the most commonly used catalysts for organic synthesis workers.


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