Di-tert-butyl decarbonate CAS# 24424-99-5

Di-tert-butyl decarbonate, Promotion Season Now in Store and Free Sample for Testing with Factory Price
  • Appearance: Transparent crystal or liquid
  • Assay: 99. 0%min
  • Packaging: 200l plastic drum
  • Sample: Available

Quality Control of Di-tert-butyl decarbonate

Chemical Structure
Di-tert-butyl dicarbonateCAS# 24424-99-5
Packing of Di-tert-butyl decarbonate

Description of Di-tert-butyl decarbonate

Di-tert-butyl dicarbonate is a reagent widely used in organic synthesis. This carbonate ester reacts with amines to give N-test-methoxycarbonyl or so-called Boc derivatives. These derivatives do not behave as amines, which allows certain subsequent transformations to occur that would have otherwise affected the amine functional group. The Boc can later be removed from the amine using acids. Thus, Boc serves as a protective group, for instance in solid-phase peptide synthesis. It is unreactive to most bases and nucleophiles, allowing for an orthogonal Fluorenylmethyloxycarbonyl chloride (FMOC-Cl) protection.

Basic Info of Di-tert-butyl decarbonate


Appearance & Physical State

White to off-white microcrystalline powder


0.95 g/mL at 25 °C(lit.)

Boiling Point

65-67 °C

Melting Point

23 °C(lit.)

Flash Point

99 °F

Refractive Index

n20/D 1.409(lit.)

Storage Condition


Safety Info



Hazard Class


Safety Statements

S16; S26; S28

HS Code


Packing Group


WGK Germany



UN 2929 6.1/PG 1

Risk Statements

R11; R19; R26; R36/37/38; R43; R10

Hazard Codes

T+; Xi; F+

Signal Word


Caution Statement

P210; P280; P304 + P340 + P310; P305 + P351 + P338 + P310; P370 + P378; P403 + P235

Hazard Declaration

H225; H315; H317; H318; H330; H335; H336


GHS02, GHS05, GHS06


Basic Info

Chemical Name

tert-butoxycarbonyl anhydride



Molecular Formula


Molecular Weight







Numbering system

MDL number


RTECS number


BRN number


EINECS number


PubChem number



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What is Di-tert-butyl decarbonate?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is  DI-TERT-BUTYL DICARBONATE which has developed particularly rapidly in recent years. Do you know about  DI-TERT-BUTYL DICARBONATE?


The official answer: Di-tert-butyl dicarbonate (Diboc) is a new type of amine protector used in organic synthesis to introduce tert-butoxy carbonyl (BOC) protectors, especially for the amine protection of amino acids. It is widely used in the synthesis of pharmaceuticals, protein and peptide synthesis, biochemistry, food and cosmetics. The finished product is colourless crystalline or colourless liquid, melting point 22~23 ℃, boiling point 56~57 ℃/66 Pa, refractive index (ND20) 1.409, relative density 0.950. soluble in organic solvents such as tetrahydrofuran, hexane, benzene and trichloromethane, slightly soluble in water. English name: Di- tert- butyl dicarbonate, C.A Nomenclature and registration number: Dicarbonic acid, bis ( 1, 1-dimethyl ethyl) ester, [24424-99- 5].

What’s the application of DI-TERT-BUTYL DICARBONATE?

Di-tert-butyl dicarbonate (Boc acid anhydride) is used in organic synthesis to introduce tert-butoxy carbonyl protection genes, especially for the amino protection of amino acids. It is widely used in the synthesis of pharmaceuticals, protein and peptide synthesis, biochemical foods, cosmetics and many other products. Amino acid BOC reagent. Used in organic synthesis to introduce tert-butoxy carbonyl (BOC) protecting groups, especially applied to amino acid protection of amino acids. Tri-Boc-protected hydrazines can be used in colouring reagents to prepare fluorenylmethoxycarbonyl? esters to monitor Chemicalbook solid-phase aldehydes. Reagents for the preparation of test-butoxy carbonyl-protected amines. Reagents for the introduction of test-butoxy carbonyl-protected groups. Alcohols such as text-butoxy carbonyl derivatives can be protected by Lewis acid catalysis. Through the test-butoxy carbonyl aminopropyl reaction with formaldehyde, diisopropylamine and copper bromide? reaction to prepare aminomethyl propadiene, a component of many bovine plasma amine oxidase inactivators? s components. It is used as an intermediate in pharmaceutical and organic synthesis and is an important amine protectant for the synthesis of pharmaceutical and agrochemical products.


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Keywords of Di-tert-butyl decarbonate




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