Ethyl chloroacetate CAS# 105-39-5

Ethyl chloroacetate, Promotion Season Now in Store and Free Sample for Testing with Factory Price
  • Appearance: Colorless liquid
  • Assay: 99.5%min
  • Packaging: 200kg/ Plastic Drum.
  • Sample: Available

Quality Control of Bretazenil

Chemical Structure
Packing of Bretazenil

Description of Ethyl chloroacetate

Ethyl chloroacetate is a chemical compound used primarily in the chemical industry. It is used as a solvent for organic synthesis and as an intermediate in the production of pesticides (such as sodium fluoroacetate).

Basic Info of Ethyl chloroacetate

Basic Info

Chemical Name

Ethyl chloroacetate


ethyl 2-chloroacetate;Acetic acid, chloro-, ethyl ester;Chloroacetic Acid Ethyl Ester;



Molecular Formula


Molecular Weight







Safety Info



Hazard Class


Safety Statements


HS Code


Packing Group


WGK Germany



UN 1181

Risk Statements

R10; R23/24/25; R50

Hazard Codes




Appearance & Physical State

Clear liquid



Boiling Point


Melting Point


Flash Point


Refractive Index


Water Solubility

20 g/L (20 ºC)


Stable. Incompatible with acids, bases, oxidizing agents, reducing agents. Flammable.

Storage Condition

Flammables area

Vapor Pressure

10 mm Hg ( 38 °C)


Numbering system

PubChem number


RTECS number


EINECS number


BRN number


MDL number



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What is Ethyl chloroacetate?

Part I: Introduction

     With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Ethyl chloroacetate which has developed particularly rapidly in recent years. Do you know about Ethyl chloroacetate?


The official answer: Ethyl chloroacetate is an organic compound with the structural formula ClCH2COOC2H5. It is a colorless and transparent liquid. It has a pungent and irritating odor. It decomposes in hot water or alkali. Miscible with ethanol and ether, insoluble in water. Relative density (d204) 1.1498. freezing point -26℃. Refractive index (n20D) 1.4227. flammable. Toxic, LD50 (rabbit, skin) 230 mg/kg. its vapor can strongly irritate the eyes and has tear-jerking properties. Used as raw material for pharmaceuticals and spices, also used as a solvent.

What’s the application of Ethyl chloroacetate?

Used as a solvent, also used as raw material for organic synthesis use as a pharmaceutical, spice, also used as solvent use ethyl chloroacetate can be used as raw material for the preparation of insecticide azoxystrobin and herbicide ethyl chlorothalonil, also used in the synthesis of antitumor drug 5-fluorouracil and spices, etc. Used as a solvent and raw material for organic synthesis. Used to make the antitumor drug 5-fluorouracil, spices, and toxic gas. Used as a solvent for organic synthesis, used as a solvent and raw material for organic synthesis. Used to make anti-tumor drug 5-fluorouracil, fragrance, and military gas. Produced by esterification of chloroacetic acid with ethanol. Direct esterification of chloroacetic acid and ethanol with sulfuric acid as catalyst. The crude ester is neutralized by alkali washing, water washing, and distillation to obtain the finished product. Chloroacetic acid B Chemicalbook ester is obtained by esterification of chloroacetic acid and ethanol catalyzed by sulfuric acid. The reaction equation is as follows: ClCH2COOH+C2H5OH[H2SO4]→ClCH2COOC2H5+H2O Add chloroacetic acid, ethanol, and benzene to the esterification pot, turn on the stirrer, slowly add sulfuric acid, heat to reflux, continuously evaporate benzene-water azeotropes, by condensing, separator stratification to the water generated by esterification, and reflux benzene to the esterification pot, when there is no longer water evaporation Cooling, discharge, crude ester washed with saturated sodium bicarbonate solution and water to neutral, dried by anhydrous calcium chloride and then distilled, collected 144-146 ℃ fraction is ethyl chloroacetate finished product, content ≥ 99.0%, yield 85%.


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