Guanidine Hydrochloride
CAS# 50-01-1

Guanidine Hydrochloride, Promotion Season Now in Store and Free Sample for Testing with Factory Price
  • Appearance: White crystalline powder
  • Assay: 99%min
  • Packaging : 25kg/per bag.
  • Sample: Available

Quality Control of Guanidine Hydrochloride

Chemical Structure
Packing of Bretazenil

Description of Guanidine Hydrochloride

Bretazenil (Ro16-6028) is an imidazopyrrolobenzodiazepine anxiolytic drug which is derived from the benzodiazepine family, and was invented in 1988.

It is most closely related in structure to the benzodiazepine antagonist flumazenil, although its effects are somewhat different. It is classed as a high-potency benzodiazepine due to its high affinity binding to benzodiazepine binding sites where it acts as a partial agonist. Its profile as a partial agonist and preclinical trial data suggests that it may have a reduced adverse effect profile. In particular bretazenil has been proposed to cause a less strong development of tolerance and withdrawal syndrome.

Bretazenil differs from traditional 1,4-benzodiazepines by being a partial agonist and because it binds to α1, α2, α3, α4, α5 and α6 subunit containing GABAA receptor benzodiazepine receptor complexes. 1,4-benzodiazepines bind only to α1, α2, α3 and α5 GABAA benzodiazepine receptor complexes.

Basic Info of Guanidine Hydrochloride

Basic Info
Chemical NameGuanidine hydrochloride
SynonymsGUANIDIUM CHLORIDE;Aminoformamidine hydrochloride,Guanidinium chloride,Guanidium chloride;Aminoformamidine hydrochloride,Aminomethanamidine hydrochloride,Guanidinium chloride;Guanidine Hydrochloride;GdmCl;Expand
CAS No.50-01-1
Molecular FormulaCH6ClN3
Molecular Weight95.53140
Appearance & Physical StateWhite cryst. powder
Boiling Point132.9ºC at 760 mmHg
Melting Point179-186ºC
Flash Point34.2ºC
Refractive Indexn20/D 1.465
Water Solubility2280 g/L (20 ºC)
StabilityStable. Hygroscopic. Incompatible with strong oxidizing agents.
Storage ConditionStore at RT.
Numbering system
MDL numberMFCD00013026
Safety Info
Safety StatementsS22
HS Code2925290090
WGK Germany1
Risk StatementsR22; R36/38
Hazard CodesXn
Signal WordWarning
Hazard DeclarationH302 + H332; H315; H319
Caution StatementP261; P280; P301 + P312 + P330; P304 + P340 + P312; P305 + P351 + P338; P337 + P313
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What is Guanidine Hydrochloride?

Part I: Introduction

With the development of technology and social progress, machinery, medicine, cosmetics, electronics, industry, and so on are all penetrating people’s daily life. One of these products is guanidine hydrochloride, which has developed particularly rapidly.

The official answer: Guanidine hydrochloride is an organic substance with the chemical formula CH6ClN3, a white or slightly yellow lump. It is used as an intermediate in pharmaceuticals, pesticides, dyes, and other organic synthetics. It is an important raw material for the manufacture of sulphonamides and folic acid and is also used as an antistatic agent in synthetic fibers.


How does guanidine hydrochloride work?


Part 2: In-depth

It is unstable and can be hydrolyzed in an aqueous solution to produce ammonia and urea, so it is as toxic as urea, and guanidine and its derivatives are generally more toxic than urea.


  1. Used as intermediate in medicine, pesticide, dyestuff, and another organic synthesis. It can be used to synthesize 2-aminopyrimidine, 2-amino-6-methyl pyrimidine, 2-amino-4,6-dimethylpyrimidine, and is an intermediate in the manufacture of sulfadiazine, sulfa-dimethyl pyrimidine, sulfa-dimethyl pyrimidine, and other sulfonamide drugs.
  2. guanidine hydrochloride (or guanidine nitrate) reacts with ethyl cyanoacetate and cyclizes to 2,4-diamino-6-hydroxypyrimidine, which is used in the synthesis of the anti-anemic drug folic acid. It is also used as an antistatic agent for synthetic fibers.
  3. Also used as a protein denaturant.
  4. Used as a strong denaturant in experiments to extract total cellular RNA. The guanidine hydrochloride solution dissolves proteins, leading to disruption of the cell structure, destruction of the nucleoprotein secondary structure, and dissociation from the nucleic acid, in addition, RNA enzymes can be inactivated by reducing agents such as guanidine hydrochloride.

Part III: Summary

Sincere to the customer and in good faith of quality is our forever followed motto. It’s the basement to be a human and do business. We take all responsibility for our products and service sincerely. We are a company integrating R&D, production, and sales. The design, research, and development of pharmaceutical intermediates including more than 330 kinds of pharmaceutical intermediates such as Anti-infectives, Cardiovascular and Cerebrovascular Systems, Digestive System, Santi-tumor, Nervous System, Geriatric Drugs, and Gynecological Drugs. At the same time, we have more than 4,000 factories in strategic cooperation with nearly 50,000 chemical products, so we can provide you with a one-stop purchasing service, which greatly saves customers’ procurement costs and time.

Hello, I’m Pew Ni, the chemical products one-stop solution expert.

Hi, I‘m Peter Ni, the founder of Sincere-Chem, I’ve been running a company in China that exporting chemicals, pharmaceuticals, and intermediates for over 70 countries now. And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.

CEO Email:

CEO Phone Number:
+86-188-6575 9396

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United Kingdom Giles
United Kingdom Giles
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Peter has been my partner for many years, we met at the Shanghai CPHI Fair in 2014, for the first time I didn't have much interest in Peter's products because our company had a stable supplier. Although we didn't work together, Peter would often send me important news and interesting trend information about the industry, so we became good friends, even though I didn't place any orders with him during this time, even if it was a sample order. In September 2016, our original supplier was unable to provide us with the quality and delivery guarantees we needed, so I first thought of Peter and his company. Until now, we have maintained a very good personal friendship in addition to a steady business relationship.
India Shikhar
India Shikhar
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In all my years of sourcing from China, I first time to found that working with Sincere Chemical was so good, they helped me with all the production and delivery as well as a lot of technical expertise, which saved me a lot of time. When I first approached Peter for a quotation for Optical Brightener, he made me a detailed quotation with not only prices but also foreign trade details, company profile, company strengths, R&D capabilities, production capacity, packaging methods, raw material control, environmental protection, and much more. This information was a very important reference for me in making purchasing decisions. Sincere Chemical is a trustworthy supplier and I believe our business will grow from strength to strength!
Korea Kim
Korea Kim
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Hi, I'm Kim, I'm Peter's partner and although I don't like him very much (because he never gives me more money for my prices, hahaha) I'm still willing to write him customer feedback. As an international buyer, I have to deal with a lot of things every day and my inbox is often full of development letters. It's a lot of junk and meaningless pleasantries, which I don't like that much, but Peter's emails always give me a better understanding of the product and the industry. I am also very pleased with his work ethic, and I am very happy with his work every time I work with him, not only in providing quotations but also in facilitating all the details of my work so that I can concentrate more on other things, so he is the best supplier for me. Although his prices are not the lowest among all suppliers, his products give me the greatest peace of mind.
USA Franklin
USA Franklin
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Sincere Chemical team visited our USA factory in the year of 2017. We think highly of cooperation with them. We thanked you for the past excellent orders and best product quality. We also talked about some new products for future orders. We will be still in strategic cooperation in the future and help each other.
Canada Kate
Canada Kate
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I just got the product. The quality is awesome. I’m very happy. Hope to place soon a new order in your company. Also wish for our future business.
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Sincere Chemical is a reliable and professional company. Not only on exporting but also their professional team service. Their team gave us so many suggestions for our new project. We are really satisfied with their awesome service and best product quality. Sincere-Chem’s vendor code is 51465768 in our cooperated vendor list system.
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I have visited Sincere Chemical company in the year 2018. Their company can be considered as one of the most professional, customer-focused, and product quality-driven companies that I have worked with in recent years.
Brazil Aline
Brazil Aline
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We are a pharmaceutical products manufacturer in Brazil. I’m happy to cooperate with Sincere Chemical especially cooperate with Peter. Peter is patient and friendly. I’m satisfied with his 24*7 hours service. We are not only cooperators but also best friends with each other.
Mexico Gonzalo
Mexico Gonzalo
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Great service and very supportive. This is my first order and I feel fortunate to be with Peter and his company. Product received was the right good quality product, so my review is more related with the quality, service and shipment. Thank you for sending. next time I will order again. Good supplier...