Guanidine thiocyanate
CAS# 593-84-0

Guanidine thiocyanate, Promotion Season Now in Store and Free Sample for Testing with Factory Price
  • Appearance: White crystalline powder
  • Assay: 99.5%min
  • Packaging: 25kg/Fiber drum.
  • Sample: Available

Quality Control of Guanidine thiocyanate

Chemical Structure
Packing of Bretazenil

Description of Guanidine thiocyanate

The official answer: Guanidine thiocyanate is a denaturing agent and is used routinely in RNA isolation. It is used as a storage buffer for whole blood samples. Guanidine thiocyanate inactivates nucleases and is ideal for storing and freezing fecal samples for DNA studies. It is used in combination with phenol−chloroform in RNA extraction.

Basic Info of Bretazenil

Safety Info



Hazard Class


Safety Statements


HS Code


WGK Germany


Packing Group



UN 1759

Risk Statements

R20/21/22; R32; R52/53

Hazard Codes


Supplemental Hazard Statements

Contact with acids liberates very toxic gas.

Hazard Declaration

H302 + H312 + H332; H314; H412

Caution Statement

P260; P280; P301 + P312 + P330; P303 + P361 + P353; P304 + P340 + P310; P305 + P351 + P338

Signal Word



GHS05, GHS07



Appearance & Physical State

white powder


1.103 g/mL at 20ºC

Boiling Point

132.9ºC at 760 mmHg

Melting Point


Flash Point


Refractive Index

n20/D 1.482


Stability Stable, but light sensitive. Incompatible with acids (contact releases very toxic gas), strong oxidising agents.

Storage Condition

Store at RT.

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What is Guanidine thiocyanate?

Part I: Introduction

     With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Guanidine Thiocyanate which has developed particularly rapidly in recent years. Do you know about Guanidine Hydrochloride?

The official answer: Guanidine thiocyanate is a denaturing agent and is used routinely in RNA isolation. It is used as a storage buffer for whole blood samples. Guanidine thiocyanate inactivates nucleases and is ideal for storing and freezing fecal samples for DNA studies. It is used in combination with phenolchloroform in RNA extraction.

What’s the application of guanidine thiocyanate?

Part 2: In-depth development

Guanidine thiocyanate is one of the cheapest and easiest to prepare for guanidine salts. Guanidine Thiocyanate is an ultrapure, molecular biology grade reagent. It is free of detectable nuclease and protease activity and is a strong protein denaturant, as both the guanidinium cation and the thiocyanate anion are chaotropic agents. It is provided in one bottle containing 500 g. It is recommended for the isolation of RNA, especially for tissues such as the pancreas with high levels of RNase activity. In solution, it is known as guanidinium thiocyanate. Guanidine Thiocyanate is thoroughly tested for contaminating nonspecific endonuclease, exonuclease, and RNase activity.

It is mainly used for biomedicine, chemical reagents.

Guanidine thiocyanate is a potent protein denaturant (stronger than guanidine HCl) often used in the isolation of intact ribonucleic acid to eliminate RNase activity. RNase can recover activity after boiling but is irreversibly inactivated in a 4 M solution of guanidine thiocyanate. Such solutions, to which the reducing agent b-mercaptoethanol is often added, are used to inactivate RNAse when isolating RNA from tissues that are rich in RNase, such as the liver. Total nuclear and cytoplasmic RNA may be isolated this way. A protocol for extracting RNA with guanidine isothiocyanate has been published.

In the presence of guanidine thiocyanate, proteins dissolve readily, cellular structures disintegrate and nucleoproteins dissociate from nucleic acids, as protein secondary structure is lost.


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