Imidazole CAS# 288-32-4

Imidazole, Promotion Season Now in Store and Free Sample for Testing with Factory Price
  • Appearance: White crystal.
  • Assay: 99. 0%min.
  • Packaging: 25kg/drum.
  • Sample: Available.

Quality Control of Imidazole

Chemical Structure
Packing of Imidazole

Description of Imidazole

Imidazole is a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.

Basic Info of Imidazole

Basic Info

Chemical Name






Molecular Formula


Molecular Weight







Safety Info



Hazard Class


Safety Statements


HS Code


Packing Group


WGK Germany



UN 1759

Risk Statements

R22; R34; R63

Hazard Codes


Hazard Declaration

H302; H314; H360D

Signal Word


Caution Statement

P201; P260; P280; P303 + P361 + P353; P305 + P351 + P338; P308 + P313


GHS05, GHS07, GHS08



Appearance & Physical State

white to yellow crystals or powder,with an amine odour


1.116 g/cm3

Boiling Point


Melting Point


Flash Point


Refractive Index


Water Solubility

633 g/L (20 ºC)


Stable. Incompatible with acids, strong oxidizing agents. Protect from moisture.

Storage Condition


Vapor Pressure

<1 mm Hg ( 20 °C)


Numbering system

MDL number


EINECS number



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What is Imidazole?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Imidazole which has developed particularly rapidly in recent years. Do you know about Imidazole?


The official answer: Imidazole, with molecular formula C3H4N2, is an organic compound, a type of diazole, a five-membered aromatic heterocyclic compound containing two interposition nitrogen atoms in the molecular structure. The unshared electron pair of the 1-position nitrogen atom in the imidazole ring is involved in cyclic conjugation, and the electron density of the nitrogen atom is reduced, making the hydrogen on this nitrogen atom easy to leave as hydrogen ions. Imidazole is acidic and also basic and can form salts with strong bases. The chemical properties of imidazole can be summarized with the synthesis of pyridine and pyrrole, two structural units that play an important role precisely in the enzyme histidine as an acyl transfer reagent in the catalysis of lipid-like hydrolysis. Derivatives of imidazole are present in biological organisms and are more important in scientific research and industrial production than imidazole itself, e.g. DNA, hemoglobin, etc.

What’s the application of Imidazole?

Imidazole is slightly more basic than pyrazole and can produce stable salts such as picrate and nitrate. One use of imidazole is in metal chelate affinity chromatography (IMAC) for the pure Chemicalbook chemistry of His-tagged proteins. The tagged protein binds to the nickel ion medium inside the bead pore on the surface of the chromatography column, and an excess of imidazole passes through the column, eluting the tagged protein ligated to nickel and yielding a high purity target protein. Imidazole is an important fine chemical raw material, mainly used in the synthesis of pharmaceuticals and pesticides and epoxy resin curing agent, used as a raw material for pesticides, used as a synergist for boric acid preparations, to make insecticides and fungicides. Used as an epoxy resin curing agent, can improve the bending, tensile, compression, and other mechanical properties of products, improve the electrical properties of insulation, improve the chemical properties of chemical resistance, widely used in computers, electrical Chemicalbook ware. Used in medicine for imidazole antifungal drugs, is one of the main raw materials of dibenzimidazole, econazole, ketoconazole, clotrimazole, and other drugs, can be used as copper antirust agent for printed circuit plates and integrated circuits. It is also used as the raw material of urea-formaldehyde resin curing agent, photographic drug, adhesive, paint, rubber vulcanizing agent, antistatic agent, etc., and intermediate of organic synthesis, and also widely used as a preservative of fruits. Colorless prismatic crystal, weakly alkaline. Easily soluble in water, ethanol, ether, chloroform, pyridine, slightly soluble in benzene, insoluble in petroleum ether. Imidazole is the intermediate of fungicides such as pesticide inhibition, miconazole, etc. It is also the intermediate of pharmaceutical antifungal drug dibenzimidazole, econazole, ketoconazole, clotrimazole. Used as organic synthesis raw materials and intermediates for the production of drugs and insecticides. Used as analytical reagent, also used in organic synthesis. Imidazole can be used as an epoxy resin curing agent, can improve the bending, tensile, compression, and other mechanical properties of products, improve the electrical properties of insulation, improve the chemical properties of chemical resistance, widely used in computers, electrical appliances; as a copper rust inhibitor and used in printed circuit plates and integrated circuits; used as pharmaceutical raw materials, used in the manufacture of antifungal drugs, anti-mold agents, low blood Chemicalbook sugar treatment drugs, artificial plasma, In addition, imidazole is also used as raw materials for urea-formaldehyde resin curing agent, photographic drugs, adhesives, coatings, rubber vulcanizing agent, anti-static agent, etc.; organic synthesis intermediates. Pesticide intermediates: fungicide intermediates: triazole fungicide. As intermediates of the pharmaceutical industry, it is used to prepare antifungal drugs such as clotrimazole, miconazole, econazole, and ketoconazole; used as a curing agent of epoxy resin; used as the raw material of Chemicalbook imidazole derivatives such as glyburide and carbonyl diimidazole; effective buffer in pH 6.2-7.8 range; used for aspartic acid and glutamic acid titration. Zinc plating brightening agent. Determination of cobalt. Organic synthesis. Used as an anti-metabolic, anti-histamine. pH 6.2-7.8 range, as a buffer. Aspartic acid and glutamic acid titration. Imidazoles are mainly used as curing agents for epoxy resins, accounting for less than half of the consumption of imidazoles in Japan, the amount of 0.5%-10% of the epoxy resin imidazoles can be used as antifungal drugs, antifungal agents, hypoglycemia treatment drugs, artificial plasma, etc. They can also be used as treatment, artificial plasma, etc. They can also be used as drugs for trichomoniasis and turkey blackhead disease. Imidazole is one of the main raw materials in the production of imidazole antifungal drugs dibenzimidazole, econazole, ketoconazole, clotrimazole. Imidazole, a fruit fungicide, can be produced from imidazole and 2,4,ω-trichloroacetophenone as the main raw material. Add 2,4,ω-trichloroacetophenone to anhydrous methanol, heat to reflux, and add bromine dropwise. Allow the solution to cool to 0°C after the color gradually disappears, add Chemicalbook into imidazole and stir vigorously for 3 h. Then evaporate the methanol under reduced pressure. The remaining liquid was poured into water, extracted with dichloromethane, the extract recovered dichloromethane and added dilute nitric acid into salt, recrystallized with water, and then treated with ammonia to obtain 2′,4′-dichloro-2-imidazole acetophenone. It was further reduced with sodium borohydride to the corresponding alcohol and finally made by allyl chlorination in the presence of sodium hydroxide and dimethylformamide to produce Imidazole (Enilconazde, also known as Enconazole). The structure and production methods of Imidazole and dibenzimidazole (miconazole) have some commonalities. While dibenzimidazole is a broad-spectrum fungal protection drug, miconazole is also an antifungal agent but is widely used as a preservative for fruits (also known as Imazalil).


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Keywords of Imidazole

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