Methotrexate CAS# 59-05-2

Methotrexate, Promotion Season Now in Store and Free Sample for Testing with Factory Price
  • Appearance: Yellow crystalline powder.
  • Assay: 99.82%min.
  • Packaging: 25kg/ Fiber Drum.
  • Sample: Available.

Quality Control of Methotrexate

Chemical Structure
Methotrexate CAS# 59-05-2
Packing of Methotrexate

Description of Methotrexate

Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions. Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma. Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn’s disease. It can be given by mouth or by injection.
Common side effects include nausea, feeling tired, fever, increased risk of infection, low white blood cell counts, and breakdown of the skin inside the mouth. Other side effects may include liver disease, lung disease, lymphoma, and severe skin rashes. People on long term treatment should be regularly checked for side effects. It is not safe during breastfeeding. In those with kidney problems lower doses may be needed. It acts by blocking the body’s use of folic acid.
Methotrexate was first made in 1947 and came into medical use initially to treat cancer as it was less toxic than other avaliable agents. It is on the World Health Organization’s List of Essential Medicines, the most important medications needed in a basic health system. Methotrexate is available as a generic medication. The wholesale cost as of 2014 in the developing world is between 0.06 and 0.36 USD per day for the form taken by mouth. In the United States a typical month of treatment costs 25 to 50 USD.

Basic Info of Methotrexate

Basic Info

Chemical Name

Methotrexate

Synonyms

Mexate;(2S)-2-[(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)amino]pentanedioic acid;4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid;MTX;Rheumatrex;Expand

CAS No.

59-05-2

Molecular Formula

C20H22N8O5

Molecular Weight

454.43900

PSA

210.54000

LogP

1.82170

Safety Info

RTECS

MA1225000

Hazard Class

6.1(b)

Safety Statements

S53-S26-S36/37-S45

HS Code

2933990090

Packing Group

III

WGK Germany

3

RIDADR

UN 1544

Risk Statements

R61; R25; R36/38

Hazard Codes

T

 

Properties

Appearance & Physical State

yellow crystalline powder

Density

1.536 g/cm3

Melting Point

195ºC

Water Solubility

Insoluble.

Stability

Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.

Storage Condition

-20ºC

 

Numbering system

MDL number

MFCD00064370

 

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What is Methotrexate?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Methotrexate which has developed particularly rapidly in recent years. Do you know about Methotrexate?

 

The official answer: Methotrexate, an anti-folate antitumor agent, mainly inhibits the growth and reproduction of tumor cells by hindering the synthesis of tumor cells through the inhibition of dihydrofolate reductase.

On October 27, 2017, the World Health Organization’s International Agency for Research on Cancer published a preliminary list of carcinogens for reference, and methotrexate is in the list of Class 3 carcinogens (substances or mixtures that are not yet classified as carcinogenic to humans).

What’s the application of Methotrexate?

(1) Systemic drug for the treatment of choriocapillaris epithelial carcinoma, malignant staphyloma, various types of acute leukemia, breast cancer, lung cancer, head and neck cancer, gastrointestinal tract cancer, cervical cancer, and malignant lymphoma, etc.

(2) Arterial cannula infusion has a good effect on head and neck cancer and liver cancer.

(3) High-dose methotrexate supplemented with calcium formyl tetrahydrofolate rescue (HDMTX-CFR therapy), like osteosarcoma, soft tissue sarcoma, malignant lymphoma, acute lymphoblastic leukemia, breast cancer, ovarian cancer. Small cell lung cancer and other postoperative adjuvant chemotherapy or systemic treatment of advanced lesions have certain efficacy.

(4) Methotrexate was started in 1988 for the treatment of rheumatoid arthritis (RA). The combination of methotrexate with biological agents such as adalimumab can be more effective in relieving disease symptoms, slowing the progression of joint damage (as shown by X-ray), and improving physical function in RA patients. Compared with conventional drugs, biologics such as adalimumab have strong and long-lasting efficacy and are well tolerated.

(5) Localized fetal sac injections in ectopic pregnancy may also be used to alleviate bleeding.

Conclusion

Sincere to the customer and in good faith of quality is our forever followed motto. It’s the basement to be a human and do business. We take all responsibility for our products and service sincerely. We are a company integrating R&D, production, and sales. The design, research, and development of pharmaceutical intermediates including more than 330 kinds of pharmaceutical intermediates such as Anti-infectives, Cardiovascular and Cerebrovascular Systems, Digestive System, Santi-tumor, Nervous System, Geriatric Drugs, and Gynecological Drugs. At the same time, we have more than 4,000 factories in strategic cooperation with nearly 50,000 chemical products, so we can provide you with a one-stop purchasing service, which greatly saves customers’ procurement costs and time.

Hello, I’m Pew Ni, the chemical products one-stop solution expert.

Hi, I‘m Peter Ni, the founder of Sincere-Chem, I’ve been running a company in China that exporting chemicals, pharmaceuticals, and intermediates for over 70 countries now. And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.

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Peter has been my partner for many years, we met at the Shanghai CPHI Fair in 2014, for the first time I didn't have much interest in Peter's products because our company had a stable supplier. Although we didn't work together, Peter would often send me important news and interesting trend information about the industry, so we became good friends, even though I didn't place any orders with him during this time, even if it was a sample order. In September 2016, our original supplier was unable to provide us with the quality and delivery guarantees we needed, so I first thought of Peter and his company. Until now, we have maintained a very good personal friendship in addition to a steady business relationship.
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In all my years of sourcing from China, I first time to found that working with Sincere Chemical was so good, they helped me with all the production and delivery as well as a lot of technical expertise, which saved me a lot of time. When I first approached Peter for a quotation for Optical Brightener, he made me a detailed quotation with not only prices but also foreign trade details, company profile, company strengths, R&D capabilities, production capacity, packaging methods, raw material control, environmental protection, and much more. This information was a very important reference for me in making purchasing decisions. Sincere Chemical is a trustworthy supplier and I believe our business will grow from strength to strength!
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