Methotrexate CAS# 59-05-2

Methotrexate, Promotion Season Now in Store and Free Sample for Testing with Factory Price
  • Appearance: Yellow crystalline powder.
  • Assay: 99.82%min.
  • Packaging: 25kg/ Fiber Drum.
  • Sample: Available.

Quality Control of Methotrexate

Chemical Structure
Methotrexate CAS# 59-05-2
Packing of Methotrexate

Description of Methotrexate

Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions. Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma. Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn’s disease. It can be given by mouth or by injection.
Common side effects include nausea, feeling tired, fever, increased risk of infection, low white blood cell counts, and breakdown of the skin inside the mouth. Other side effects may include liver disease, lung disease, lymphoma, and severe skin rashes. People on long term treatment should be regularly checked for side effects. It is not safe during breastfeeding. In those with kidney problems lower doses may be needed. It acts by blocking the body’s use of folic acid.
Methotrexate was first made in 1947 and came into medical use initially to treat cancer as it was less toxic than other avaliable agents. It is on the World Health Organization’s List of Essential Medicines, the most important medications needed in a basic health system. Methotrexate is available as a generic medication. The wholesale cost as of 2014 in the developing world is between 0.06 and 0.36 USD per day for the form taken by mouth. In the United States a typical month of treatment costs 25 to 50 USD.

Basic Info of Methotrexate

Basic Info

Chemical Name



Mexate;(2S)-2-[(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)amino]pentanedioic acid;4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid;MTX;Rheumatrex;Expand



Molecular Formula


Molecular Weight






Safety Info



Hazard Class


Safety Statements


HS Code


Packing Group


WGK Germany



UN 1544

Risk Statements

R61; R25; R36/38

Hazard Codes




Appearance & Physical State

yellow crystalline powder


1.536 g/cm3

Melting Point


Water Solubility



Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.

Storage Condition



Numbering system

MDL number



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What is Methotrexate?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Methotrexate which has developed particularly rapidly in recent years. Do you know about Methotrexate?


The official answer: Methotrexate, an anti-folate antitumor agent, mainly inhibits the growth and reproduction of tumor cells by hindering the synthesis of tumor cells through the inhibition of dihydrofolate reductase.

On October 27, 2017, the World Health Organization’s International Agency for Research on Cancer published a preliminary list of carcinogens for reference, and methotrexate is in the list of Class 3 carcinogens (substances or mixtures that are not yet classified as carcinogenic to humans).

What’s the application of Methotrexate?

(1) Systemic drug for the treatment of choriocapillaris epithelial carcinoma, malignant staphyloma, various types of acute leukemia, breast cancer, lung cancer, head and neck cancer, gastrointestinal tract cancer, cervical cancer, and malignant lymphoma, etc.

(2) Arterial cannula infusion has a good effect on head and neck cancer and liver cancer.

(3) High-dose methotrexate supplemented with calcium formyl tetrahydrofolate rescue (HDMTX-CFR therapy), like osteosarcoma, soft tissue sarcoma, malignant lymphoma, acute lymphoblastic leukemia, breast cancer, ovarian cancer. Small cell lung cancer and other postoperative adjuvant chemotherapy or systemic treatment of advanced lesions have certain efficacy.

(4) Methotrexate was started in 1988 for the treatment of rheumatoid arthritis (RA). The combination of methotrexate with biological agents such as adalimumab can be more effective in relieving disease symptoms, slowing the progression of joint damage (as shown by X-ray), and improving physical function in RA patients. Compared with conventional drugs, biologics such as adalimumab have strong and long-lasting efficacy and are well tolerated.

(5) Localized fetal sac injections in ectopic pregnancy may also be used to alleviate bleeding.


Sincere to the customer and in good faith of quality is our forever followed motto. It’s the basement to be a human and do business. We take all responsibility for our products and service sincerely. We are a company integrating R&D, production, and sales. The design, research, and development of pharmaceutical intermediates including more than 330 kinds of pharmaceutical intermediates such as Anti-infectives, Cardiovascular and Cerebrovascular Systems, Digestive System, Santi-tumor, Nervous System, Geriatric Drugs, and Gynecological Drugs. At the same time, we have more than 4,000 factories in strategic cooperation with nearly 50,000 chemical products, so we can provide you with a one-stop purchasing service, which greatly saves customers’ procurement costs and time.

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United Kingdom Giles
United Kingdom Giles
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Peter has been my partner for many years, we met at the Shanghai CPHI Fair in 2014, for the first time I didn't have much interest in Peter's products because our company had a stable supplier. Although we didn't work together, Peter would often send me important news and interesting trend information about the industry, so we became good friends, even though I didn't place any orders with him during this time, even if it was a sample order. In September 2016, our original supplier was unable to provide us with the quality and delivery guarantees we needed, so I first thought of Peter and his company. Until now, we have maintained a very good personal friendship in addition to a steady business relationship.
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India Shikhar
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In all my years of sourcing from China, I first time to found that working with Sincere Chemical was so good, they helped me with all the production and delivery as well as a lot of technical expertise, which saved me a lot of time. When I first approached Peter for a quotation for Optical Brightener, he made me a detailed quotation with not only prices but also foreign trade details, company profile, company strengths, R&D capabilities, production capacity, packaging methods, raw material control, environmental protection, and much more. This information was a very important reference for me in making purchasing decisions. Sincere Chemical is a trustworthy supplier and I believe our business will grow from strength to strength!
Korea Kim
Korea Kim
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Hi, I'm Kim, I'm Peter's partner and although I don't like him very much (because he never gives me more money for my prices, hahaha) I'm still willing to write him customer feedback. As an international buyer, I have to deal with a lot of things every day and my inbox is often full of development letters. It's a lot of junk and meaningless pleasantries, which I don't like that much, but Peter's emails always give me a better understanding of the product and the industry. I am also very pleased with his work ethic, and I am very happy with his work every time I work with him, not only in providing quotations but also in facilitating all the details of my work so that I can concentrate more on other things, so he is the best supplier for me. Although his prices are not the lowest among all suppliers, his products give me the greatest peace of mind.
USA Franklin
USA Franklin
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Canada Kate
Canada Kate
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I just got the product. The quality is awesome. I’m very happy. Hope to place soon a new order in your company. Also wish for our future business.
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Brazil Aline
Brazil Aline
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Mexico Gonzalo
Mexico Gonzalo
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Great service and very supportive. This is my first order and I feel fortunate to be with Peter and his company. Product received was the right good quality product, so my review is more related with the quality, service and shipment. Thank you for sending. next time I will order again. Good supplier...