Piperonyl butoxide CAS# 51-03-6

Piperonyl butoxide, Promotion Season Now in Store and Free Sample for Testing with Factory Price
  • Appearance: Colorless to light yellow oil liquid
  • Assay: 95%min
  • Packaging: 200kg/Steel Drum
  • Sample: Available

Quality Control of Piperonyl butoxide

Chemical Structure
Packing of Bretazenil

Description of Piperonyl butoxide

Piperonyl butoxide (PBO) is an organic compound used as a component of pesticide formulations. It is a waxy white solid. It is a synergist. That is, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone. It is a semisynthetic derivative of safrole.

Basic Info of Bretazenil

Basic Info

Chemical Name

piperonyl butoxide


INCITE;PRENTOX;Piperonyl butoxide;Butocide;Vex;Expand



Molecular Formula


Molecular Weight







Safety Info



Hazard Class


Safety Statements


WGK Germany


Packing Group



UN 2810

Risk Statements

R24; R51/53

Hazard Codes




Appearance & Physical State

amber coloured liquid



Boiling Point

180ºC (1 mmHg)

Flash Point


Refractive Index



Stable. Combustible. Incompatible with oxidizing agents.

Storage Condition



Numbering system

MDL number



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What is Piperonyl butoxide?

Part I: Introduction

     With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is piperonyl butoxide which has developed particularly rapidly in recent years. Do you know about Piperonyl butoxide?

The official answer: Piperonyl butoxide, abbreviated ENT -14250, is a colorless to light yellow oily transparent liquid. It has a slightly peculiar odor and a bitter taste. Relative density 1.059, refractive index 1.50, flash point 171ºC (open cup). Discolours easily when exposed to light. Insoluble in water, miscible with methanol, ethanol, benzene, freon, grease, and other organic solvents. Acute oral LD50 11500mg/kg in rats, acute percutaneous LD50 1880mg/kg in rabbits, non-carcinogenic.

What’s the application of piperonyl butoxide?

Part 2: In-depth development

Insecticide synergist: A U.S. EPA restricted Use Pesticide (RUP). Not listed for use in EU countries. Piperonyl butoxide is a synergist, i.e., not a pesticide itself, but enhances the properties of other chemicals. It is used with other pesticides such as pyrethrins, pyrethroids, rotenone, and carbamates in food and non-food agricultural products, home and garden products, termite and mosquito products, and veterinary pesticide products. It inhibits the insect’s ability to break down an insecticide before it takes effect, thereby prolonging the action, and reduces the necessity for using a stronger formulation.

Piperonyl butoxide is used primarily in admixture with pyrethrins and some of the pyrethroids to enhance and prolong their insecticidal action. Much of this use is in domestic and industrial situations. Metabolism studies were conducted soon after their discovery and first use in the 1950s and 1960s. The main impetus initially was to understand the mode of action as a synergist. When this was shown to be due to the inhibition of oxidative metabolism, further studies were conducted to address possible toxic interactions with other pesticides and drugs in man.

Piperonyl butoxide undergoes rapid photodegradation and microbial degradation in soil. It is also rapidly metabolized in insects and mammals by an oxidative attack at the methylenedioxy carbon atom and in the side chain. A comprehensive review by Casida (1970) describes the chemistry, mode of action, and metabolism of piperonyl butoxide and several related methylenedioxyphenyl compounds. Though published nearly 30 years ago, the review remains a very useful compilation of a large amount of information, supported by more than 300 references.


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