Quercetin CAS# 117-39-5

Quercetin , Promotion Season Now in Store and Free Sample for Testing with Factory Price
  • Appearance: Fine Powder.
  • Assay: 98. 0%min
  • Packaging: 25kg/barrel.
  • Sample: Available

Quality Control of Quercetin

Chemical Structure
Packing of Quercetin

Description of Quercetin

Quercetin is a flavonol found in many fruits, vegetables, leaves and grains. It can be used as an ingredient in supplements, beverages, or foods.

Basic Info of Quercetin

Basic Info

Chemical Name

quercetin

Synonyms

2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one;MELETIN;QUERCITIN;3,3′,4′,5,7-Pentahydroxyflavone;kvercetin;Expand

CAS No.

117-39-5

Molecular Formula

C15H10O7

Molecular Weight

302.23600

PSA

131.36000

LogP

1.98800

 

Safety Info

RTECS

LK8750000

Hazard Class

6.1(b)

Safety Statements

S28-S45

HS Code

2932999099

Packing Group

III

RIDADR

UN 2811

Risk Statements

R25; R40

Hazard Codes

T

Hazard Declaration

H301

Caution Statement

P301 + P310 + P330

Signal Word

Danger

Symbol

GHS06

 

Properties

Appearance & Physical State

Yellow to green yellow crystalline powde

Density

1.799 g/cm3

Boiling Point

642.4ºCat 760 mmHg

Melting Point

314-317ºC

Flash Point

248.1ºC

Refractive Index

1.767

Stability

Stable under normal temperatures and pressures.

Storage Condition

Store at 0-5ºC

Vapor Pressure

9.03E-16mmHg at 25°C

 

Numbering system

RTECS number

LK8750000

BRN number

317313

PubChem number

24860398

MDL number

MFCD00006828

 

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What is Quercetin?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Quercetin which has developed particularly rapidly in recent years. Do you know about Quercetin?

 

The official answer: Quercetin, which is widely distributed in the plant world, is a flavonol compound with a variety of biological activities. Quercetin can fight free radicals, complex or capture free radicals to prevent lipid peroxidation in the body; it can directly inhibit tumors and effectively play a role in cancer prevention and anti-cancer; it also has strong biological activities in antibacterial, anti-inflammatory, anti-allergic, and preventing diabetic complications. In addition, quercetin also has the effects of lowering blood pressure, enhancing capillary resistance, reducing capillary fragility, lowering blood lipids, dilating coronary arteries, increasing coronary blood flow, etc. It also has auxiliary therapeutic effects on patients with coronary heart disease and hypertension. Quercetin is non-toxic, therefore, it is important for the treatment and prevention of cancer, aging, and cardiovascular diseases, and has a greater development value.

What’s the application of Quercetin?

Quercetin, a natural flavonoid widely found in nature, has gained intensive research and has been found to have multiple biological activities, such as antioxidant, antiviral, and anti-inflammatory effects, and can be used in cellular and animal experiments to treat liver, heart, spleen, lung, kidney, orthopedic diseases, and neurological disorders.

Antioxidant effect

Quercetin is a natural chelator that can chelate iron in the body, reduce iron overload in the body, and reduce oxidative damage caused by iron overload.  Quercetin has various effects such as antioxidant, scavenging free radicals, and inhibiting lipid peroxidation, which can antioxidant and protect cardiovascular health, and has shown better effects in anti-cancer. However, the data from such studies are from cytological experiments or animal experiments, and more validation is still needed to determine whether it works directly in humans.

Tumor-inhibiting activity

In terms of anti-cancer, quercetin has been shown in numerous studies to have inhibitory effects on various cancer cells. In terms of specific mechanisms of action, quercetin has a variety of biological effects, inhibiting a variety of enzymes involved in cell proliferation and signaling pathways in cancer cells.

On the other hand, it has also been shown that quercetin has some synergistic effects when used in combination with commonly used chemotherapeutic agents or radiotherapy, and has some promise for application. For example, quercetin can act in chemosensitization and radiosensitization chemotherapy also as an antiradiation, protecting normal cells from the side effects of chemotherapy and radiotherapy, and these advantages can significantly enhance its anticancer therapeutic effects. Various flavonols such as quercetin, kaempferol, and prunetinone have some preventive and curative effects against pancreatic cancer, especially for smokers, the effects may be more pronounced.

Quercetin may exert antitumor effects by inducing apoptosis in tumor cells. The expression of glucose transporter protein is significantly increased in primary liver cancer, and inhibition of its expression could be a new therapeutic direction for primary liver cancer. In the field of gastric cancer research, quercetin was likewise found to induce apoptosis and exert anti-tumor effects by triggering mitochondrial apoptosis-dependent growth inhibition, which could be a new target for the treatment of gastric cancer.

Mechanism of lipid-lowering and weight loss

Quercetin is a rich source of flavonoids in the diet, and studies have shown its lipid-lowering and weight-loss effects.

Quercetin can inhibit the decomposition of cholesterol esters into free cholesterol and can reduce the solubility of cholesterol in micellar solutions, inhibiting the absorption of cholesterol in the small intestine, which has the purpose of lowering lipids.

Quercetin is a potent regulator of plasma TG (triglyceride) levels.

Quercetin reduces intrahepatic lipid accumulation and decreases insulin resistance and NAFLD activity scores by regulating lipid metabolism gene expression, cytochrome P4502El (CYP2E1)-dependent lipid peroxidation, and associated lipotoxicity.

Quercetin has various effects such as inhibiting the proliferation of preadipocytes, inducing apoptosis of preadipocytes, and promoting lipolysis of mature adipocytes. And it can promote lipolysis metabolism and inhibit lipogenesis.

Quercetin can reduce the expression of IL-18, elevate the expression of IL-10, and alleviate the index abnormalities brought by a high-fat diet. These experiments suggest that quercetin can effectively improve the abnormal expression of inflammatory factors caused by high fat.

Protection of the heart

Quercetin has been shown to lower blood pressure, enhance capillary resistance, reduce capillary fragility, lower blood lipids, dilate coronary arteries, and increase coronary blood flow, and also has adjuvant therapeutic effects in patients with coronary heart disease and hypertension.  

Quercetin effectively attenuates H2O2-mediated oxidative damage in cardiomyocytes, which in turn inhibits cardiomyocyte apoptosis. Treatment with quercetin significantly reduced the number of premature ventricular contractions, suggesting a significant cardioprotective effect of quercetin in coronary artery disease.

Improving cardiac function and reducing myocardial hypertrophy: the dietary polyphenol complex quercetin can effectively regulate plasma cholesterol and non-adaptive myocardial remodeling. In addition, inhibition of myocardial hypertrophy can effectively reduce mortality from cardiovascular disease.

Antiplatelet and prevent thrombosis: quercetin can effectively inhibit the formation of thrombus in diabetes, and can be used as an antiplatelet agent in diabetes treatment. It can also inhibit platelet aggregation and agonist-induced GPIIb/IIIa activation caused by collagen, adenosine diphosphate, and arachidonic acid, and quercetin can also inhibit the extracellular secretion of platelet granules.

Vasodilatation and blood pressure lowering: quercetin can lower blood pressure by reducing the elasticity of blood vessels.

Anti-atherosclerosis: quercetin can significantly reduce atherosclerotic plaque areas in the high-fat group, attenuate oxidative stress in various systems, and block the activation of NADPH oxidase, which suggests that regular consumption of quercetin in the diet plays an important role in inhibiting the formation of atherosclerosis. Quercetin can inhibit oxidant-induced endothelial dysfunction and atherosclerosis.

Lowering blood lipids and lipid peroxidation: quercetin has a certain effect of lowering blood lipids, can promote cell proliferation, and reduce triglycerides. And can inhibit the increase of lipid peroxidation, effectively reduce the accumulation of triglycerides in non-alcoholic fatty liver, insulin resistance, and the secretion of some inflammatory factors, and increase the antioxidant capacity of cells, with the increase of quercetin concentration, cholesterol concentration in red blood cells is getting lower.

Prevent myocardial ischemia-reperfusion injury: quercetin pretreatment can significantly improve myocardial function and reduce myocardial injury and infarct area while improving the improvement of oxidative damage and apoptosis of myocardium.

Hypoglycemia and alleviate insulin resistance: Quercetin can effectively improve hyperglycemia and hyperlipidemia and antioxidant status in type 2 diabetes by alleviating blood glucose uptake and improving insulin resistance status through the AMPK pathway rather than the insulin signaling pathway. In addition, quercetin induces an increase in intracellular calcium ion concentration. And AMPK pathway can play a role in reducing insulin resistance through insulin system bypass.

Effects on exercise

Exercise fatigue is associated with oxidative stress during human exercise, and studies before 2017 showed that exercise fatigue can lead to a reduction in the body’s antioxidant capacity and oxidative stress damage. The powerful antioxidant activity of quercetin may also help to reduce fatigue.

Quercetin supplementation may reduce lipid peroxidation damage by decreasing MDA levels during exercise. In addition, quercetin improves the antioxidant capacity of the body by inhibiting the decrease in SOD and GSH-Px during exercise, thereby delaying fatigue.

Antiviral activity

Quercetin significantly reduced the replication rate of hepatitis C virus, while the infectivity of quercetin-treated virus particles was found to be reduced by 65%, indicating that quercetin affected the integrity of the virus, and it was further confirmed by molecular-level experiments that quercetin could exert antiviral effects by blocking the upregulation of diacylglycerol acyltransferase by hepatitis C virus and the typical localization of hepatitis C virus core protein on the surface of lipid droplets.

Conclusion

Sincere to the customer and in good faith of quality is our forever followed motto. It’s the basement to be a human and do business. We take all responsibility for our products and service sincerely. We are a company integrating R&D, production, and sales. The design, research, and development of pharmaceutical intermediates including more than 330 kinds of pharmaceutical intermediates such as Anti-infectives, Cardiovascular and Cerebrovascular Systems, Digestive System, Santi-tumor, Nervous System, Geriatric Drugs, and Gynecological Drugs. At the same time, we have more than 4,000 factories in strategic cooperation with nearly 50,000 chemical products, so we can provide you with a one-stop purchasing service, which greatly saves customers’ procurement costs and time.

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Hi, I‘m Peter Ni, the founder of Sincere-Chem, I’ve been running a company in China that exporting chemicals, pharmaceuticals, and intermediates for over 70 countries now. And a range of 50,000 products with the best quality and competitive price to meet your different purchasing needs.

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