With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Thiabendazole which has developed particularly rapidly in recent years. Do you know about Thiabendazole?

The official answer: Thiamethoxam is a benzimidazole fungicide, the mechanism of action is to inhibit the formation of microtubulin in the process of fungal mitosis. The synthesis of thiamethoxam The mixture of 4-acetoxy carbonyl thiazole, o-phenylenediamine, and polyphosphoric acid is stirred and heated to 125℃, then heated at 175℃ for 2h, the mixture is injected into ice water, neutralized with sodium hydroxide solution to pH 6, precipitated crystals, filtered, extracted with hot acetone, the extract is decolorized with activated carbon, concentrated, dried under vacuum, and thiamethoxam is produced. The reaction between 4-thiazole carboxy acyl (or acyl bromide) and o-phenylenediamine in condensed phosphoric acid at 240℃ for 3h, the reaction product was poured into ice water, filtered and the filtrate was washed with 30% sodium hydroxide solution to Ph=6, the crystals of benzimidazole were precipitated, the crude product was obtained by filtration, washing, and drying, and then the finished product was recrystallized by ethanol.

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