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Synthesis of impurities in methotrexate Synthesis of impurities in methotrexate Objective: To synthesize three major impurities in it API. Methods: The impurity E was synthesized by cyclization of p-acid,tetraaminopyrimidine The impurity E was synthesized by cyclization, impurity D was synthesized by hydrolysis, and impurity C was obtained by hydrolysis of methotrexate. The structures of the

Synthesis process of methotrexate Abstract methotrexate methotrexate(1), chemically known as N-(4-(((2,4-diamino-6-pyridinyl)methyl)methylamino)benzoyl)-L-glutamate is a widely used antitumor drug in the field of cancer chemotherapy.111 Especially after the clinical adoption of high-dose it therapy in the past 20 years and its approval by the U.S. FDA for the treatment of rheumatoid arthritis in 1988,3 the demand for

Production process and application of isopropanol Production process and application of isopropanol Abstract It is a widely used organic solvent and raw material. The manufacturing technology of isopropanol was introduced. The economics of acetone hydrogenation and propylene hydration were compared. The application prospect of isopropanol was also analyzed. It is    considered that the route of

Global p-xylene supply and demand Global p-xylene supply and demand Abstract: The capacity of global it has been steadily increasing in recent years, and the new capacity mainly comes from the Chinese mainland, Vietnam, India, South Korea, and Saudi Arabia in the Middle East. In 2020, the global production capacity of it was 64.476 million

Acrylonitrile Production and Market​ Acrylonitrile Production and Market (Research Institute of Jilin Petrochemical Company, PetroChina, Jilin 132021 China) Abstract: The paper summarizes acrylonitrile production capacity, actual output, market demand and price both at home and abroad, analyzes the actuality and development trend of acrylonitrile plants, introduces acrylonitrile research & development and technology progress and puts

The synthesis process of methotrexate Abstract An overview of the progress of the main synthetic methods of methotrexate and the preparation of key intermediates is given. Keywords Methotrexate, synthesis Methotrexate(1),chemically known as N-(4-(((2,4-diamino-6-phthalimide)methyl)methylamino)benzoyl)-L-glutamate is a widely used antitumor drug in the field of cancer chemotherapy.111, Especially after the clinical adoption of high-dose methotrexate therapy in the