5-Methoxy-3-indoleaceate CAS 608-07-1

5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels. It is biosynthesized via the deacetylation of melatonin in the pineal gland.
5-MT acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors.[8] It has no affinity for the 5-HT3 receptor and it should also be noted that its affinity for the 5-HT1E receptor is very weak in comparison to the other 5-HT1 receptors. Its affinity for the 5-HT5A receptor is unknown.
Measured affinity for some receptors (not a complete list): 5-HT1B receptors (Ki = 35 nM) , 5-HT1D receptors (Ki = 7.3 nM), 5-HT1E receptors (Ki = 3151 nM), 5-HT1F receptors (Ki = 1166 nM), 5-HT2A receptors (Ki = 295 nM), 5-HT2B receptors (Ki = 16.4 nM), 5-HT2C receptors (Ki = 52.48 nM) , 5-HT4 receptors (Ki = 501.18 nM), 5-HT6 receptors (Ki = 69.18 nM), 5-HT7 receptors (Ki = 5.01 nM).