Afatinib CAS 850140-72-6
fatinib , Promotion Season Now in Store and Free Sample for Testing with Factory Price
Chemical Name: Afatinib
Afatinib: The Complete Guide
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Description of Afatinib
fatinib(INN; trade name Gilotrif in the US and Giotrif in Europe, previously Tomtovok and Tovok) is a drug approved in United States, Europe, Taiwan, Mexico, Chile and Japan as well as other countries for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and erbB-2 (HER2).fatinib
Basic Info of Afatinib
BIBW 2992;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-;(E)-Afatinib;Tovok;Afatinib freebase;Expand
Appearance & Physical State
100 – 102 °C
What is Afatinib?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives.
- One such product is fatinib which has developed particularly rapidly in recent years. Do you know about Afatinib?
- The official answer:Afatinib (afatinib) is a potent, irreversible dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinases.
What’s the application of Afatinib?
Like lapatinib and nalatinib, afatinib is a protein kinase inhibitor that also irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. Afatinib is not only useful against EGFR mutations targeted by first-generation tyrosine kinase inhibitors (TKI), such as erlotinib or giChemical bookfetinib, but also against less common mutations that are resistant to these drugs. However, it has no activity against T790M mutations that normally require third-generation drugs such as axitinib. Because it has additional activity against Her2, it is being studied against breast cancer as well as other EGFR and Her2-driven cancers.
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