Bestatin CAS# 58970-76-6
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Chemical Name: Bestatin
CAS No.: 58970-76-6
Molecular Fomula: C11H14O
appearance:White crystalline powder
Bestatin : The Complete Guide
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Description of Bestatin
Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia. It is derived from Streptomyces olivoreticuli. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds.
Basic Info of Bestatin
Appearance & Physical State
White crystalline powder
604.7ºC at 760 mmHg
Stable at normal temperatures and pressures.
What is Bestatin?
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The official answer: Uses Adjuvant therapy for acute and chronic cellular leukemia and other diseases
What’s the application of Bestatin?
Ubenimex (I Ubenimex; NN), also known as bestatin, with the chemical formula N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine; is a competitive, reversible protease inhibitor. It inhibits arginylaminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (zinc metalloprotease showing epoxide hydrolase and aminopeptidase activity), alanylaminopeptidase (aminopeptidase M/N), and leucyl/cystamylaminopeptidase (cathepsin/vasopressinase) (leukotriene D4 hydrolase). It is being investigated for the treatment of acute myeloid leukemia. It from Streptomyces olivoreticuli. Ubenimex has to inhibit the enzymatic degradation of oxytocin, pressin, enkephalin and various other peptides and compounds.
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