Calcium folinate Typical Properties Product Name Calcium folinate CAS 1492-18-8 MF C20H21CaN7O7 MW 511.5 Calcium folinate Usage Calcium folinate (CF) itself has no anti-tumor effect and is mainly used for high-dose rescue and concurrent use with fluorouracil to enhance the latter’s therapeutic effect. The so-called high-dose methotrexate-leucovorin (HD MTX-CF) rescue therapy is applying intravenous infusion of MTX of over 100 times higher than the conventional dose, usually at 2~5 mg/m2 for drip of 4~6 h to make the blood concentration increase to a very high level, so that intracellular MTX can reach over 10-5 mol/L or more effective concentration. In this case, it can be spread to solid tumors with poor blood supply, and reach across physiological barriers such as blood-cerebrospinal fluid and testicular. However, high-dose of MTX can have a fatal toxicity, so at a certain period of time after the MTX dripping, we must immediately take detoxification measures. CF rescue should generally start at 2 to 18 hours after the MTX dripping. Apply intramuscular injection or intravenous injection of a dose of 6~15μg/m2 at 6 hour per time with the general medication of 3d and a total of 12 times. CF dose and injection time should be associated with the application of MTX, namely being able to reduce the blood concentration of MTX to below the safety threshold: 10-7 mol/L before stopping. In addition, we should also give auxiliary hydration, alkalization treatment to support. CF formulations are generally 6 mg water injection. For the treatment of megaloblastic anemia, 15 mg orally every day; or 1~5 mg intramuscular injection every day. After 10-15 days, the dose can be reduced to 5 mg/d orally until the blood picture is normal and the symptoms disappear; if adenosylcobalamin cannot be excluded If it is lacking, it should be combined with adenosylcobalamin. For the rescue of methotrexate, 3 to 4 times a day, 5 to 15 mg orally each time for 2 days; or 3 to 6 mg intramuscular injection; methotrexate taken for more than 4 hours is invalid with this medicine. For the detoxification of pyrimethamine or trimethoprim, 5~15 mg orally every day. Calcium folinate is used in combination with fluorouracil, 20-30mg/m2, orally half an hour after fluorouracil is administered. Calcium folinate use 1. Mainly used as an antidote for folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.). 2. It is used to prevent severe toxic effects caused by methotrexate overdose or high-dose treatment. 3. Megaloblastic anemia caused by folic acid deficiency. 4. When combined with fluorouracil, it is used to treat advanced colon cancer and rectal cancer. It is used to relieve the toxic reaction caused by the overdose of aminopterin and methotrexate, and can also be used to treat giant red blood cell anemia. Calcium folinate counteracts the effect of folic acid antagonists, which are combined with folic acid dehydrogenase (dihydrofolatereductase) to prevent the conversion of folic acid to tetrahydrofolate. Medically, after methotrexate chemotherapy, leucovorin is used to reduce the toxicity of methotrexate. Leucovorin also enhances the cytotoxic effect of 5-fluorouracil in anti-cancer. Leucovorin can counteract the effects of folic acid antagonists. Folic acid works by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, leucovorin is used to reduce the toxicity of methotrexate after methotrexate treatment. Calcium folinate Packaging and Shipping Packaging:25 kg/package , as customer’s request Shipping:It can be according to the customer’s request Calcium folinate storage Store at RT.

Calcium folinate CAS 1492-18-8

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Chemical Name: Calcium folinate

CAS No.:1492-18-8

Molecular Fomula:C20H25CaN7O7

Molecular weight:515.54


Sample: Available

Calcium folinate CAS 1492-18-8

Description of CF-CA

Folinic Acid Calcium Salt is a derivative of Folic Acid , a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. Has been shown to be partially effective in the treatment children suffering from autism spectrum disorders (ASDs).

Basic Info of CF-CA

Chemical Name

Folinic acid calcium salt hydrate


Citrovorum factor calcium salt;5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt;Calcium folinate;Calcium Folinate Hydrate;5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt;Expand



Molecular Formula


Molecular Weight






Safety Info



Safety Statements


HS Code


WGK Germany


Risk Statements

R36/37/38; R42/43

Hazard Codes


Hazard Declaration

H315; H317; H319; H334; H335

Caution Statement

P261; P280; P305 + P351 + P338; P342 + P311

Signal Word



GHS07, GHS08


Appearance & Physical State

yellow crystalline powder

Melting Point



Stable at normal temperatures in tightly closed containers under an inert atmosphere.

Storage Condition

Store in a tightly closed container. Keep under an argon blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4ºC). Store protected from light and air.

Numbering system

EINECS number


RTECS number


PubChem number


BRN number


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What is CF-CA?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Calcium folinate which has developed particularly rapidly in recent years. Do you know about Calcium folinate?

The official answer:CF-CA, chemically N-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydro-6-pteridinyl)methyl]amino]benzoyl-L-glutamic acid calcium salt, is a whitish to slightly yellowish crystalline or amorphous powder; odourless. Soluble in water, practically insoluble in ethanol or ether; soluble in 0.1 mol/L sodium hydroxide solution. It is a derivative of folic acid, a vitamin required for the synthesis of DNA, for DNA repair and for methylation of DNA; it also acts as a cofactor in biological reactions involving folic acid. It has been shown to be partially effective in the treatment of children with autism spectrum disorders (ASD).

What’s the application of CF-CA?

CF-CA acid counteracts the effects of folate antagonists, which rely on binding to the enzyme dihydrofolatereductase, thereby preventing the conversion of folate Chemicalbook to tetrahydrofolate. Medically, calcium folinate is used to reduce the toxicity of methotrexate after methotrexate chemotherapy. Calcium folinate also enhances the cytotoxic effects of 5-fluorouracil in the fight against cancer.


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