Calcium folinate CAS 1492-18-8
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Chemical Name: Calcium folinate
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Description of CF-CA
Folinic Acid Calcium Salt is a derivative of Folic Acid , a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. Has been shown to be partially effective in the treatment children suffering from autism spectrum disorders (ASDs).
Basic Info of CF-CA
Folinic acid calcium salt hydrate
Citrovorum factor calcium salt;5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt;Calcium folinate;Calcium Folinate Hydrate;5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt;Expand
H315; H317; H319; H334; H335
P261; P280; P305 + P351 + P338; P342 + P311
Appearance & Physical State
yellow crystalline powder
Stable at normal temperatures in tightly closed containers under an inert atmosphere.
Store in a tightly closed container. Keep under an argon blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4ºC). Store protected from light and air.
What is CF-CA?
With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Calcium folinate which has developed particularly rapidly in recent years. Do you know about Calcium folinate?
The official answer:CF-CA, chemically N-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydro-6-pteridinyl)methyl]amino]benzoyl-L-glutamic acid calcium salt, is a whitish to slightly yellowish crystalline or amorphous powder; odourless. Soluble in water, practically insoluble in ethanol or ether; soluble in 0.1 mol/L sodium hydroxide solution. It is a derivative of folic acid, a vitamin required for the synthesis of DNA, for DNA repair and for methylation of DNA; it also acts as a cofactor in biological reactions involving folic acid. It has been shown to be partially effective in the treatment of children with autism spectrum disorders (ASD).
What’s the application of CF-CA?
CF-CA acid counteracts the effects of folate antagonists, which rely on binding to the enzyme dihydrofolatereductase, thereby preventing the conversion of folate Chemicalbook to tetrahydrofolate. Medically, calcium folinate is used to reduce the toxicity of methotrexate after methotrexate chemotherapy. Calcium folinate also enhances the cytotoxic effects of 5-fluorouracil in the fight against cancer.
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