Chloroquine diphosphate CAS 50-63-5

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Chemical Name: Chloroquine diphosphate
CAS No.: 50-63-5
Molecular Fomula: C18H32ClN3O8P2
Molecular weight:515.86
Appearance: solid
Sample: Available

Chloroquine diphosphate CAS# 50-63-5

Description of Chloroquine diphosphate

Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ.

Basic Info of Chloroquine diphosphate

Chemical Name

Chloroquine Diphosphate

Synonyms

1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, phosphate (1:2);alermine;7-Chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate;alermine;N4-(7-Chloro-4-quinolyl)-N1,N1-diethyl-1,4-pentanediamine Diphosphate;

CAS No.

50-63-5

Molecular Formula

C18H32ClN3O8P2

Molecular Weight

515.86300

PSA

203.30000

LogP

3.02640

Safety Info

RTECS

VB2450000

Hazard Class

6.1(b)

Safety Statements

S22-S24/25

HS Code

2933499090

WGK Germany

3

Packing Group

III

RIDADR

UN 1544

Risk Statements

R22

Hazard Codes

Xn

Hazard Declaration

H302

Symbol

GHS07

Signal Word

Warning

Properties

Appearance & Physical State

White Solid

Boiling Point

460.6ºC at 760 mmHg

Melting Point

200ºC

Flash Point

232.3ºC

Storage Condition

Desiccate at RT

Numbering system

UNII

6E17K3343P

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What is Chloroquine diphosphate?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is alermine which has developed particularly rapidly in recent years. Do you know about alermine?

The official answer:alermine is a 4-aminoquinoline antimalarial drug, which can inhibit the nucleic acid synthesis of Plasmodium cleavage and interfere with the growth and reproduction of Plasmodium, and is highly effective in killing Plasmodium intraerythrocytic cleavage. alermine binds strongly to nucleoproteins by the proximity of the negatively charged 7-chloro group on its quinoline ring to the 2-amino group on the guanine of DNA, allowing the insertion of chloroquine between the two strands of the double helix of DNA. It forms a complex with DNA, thus preventing the replication of DNA and the transcription of RNA. 

What’s the application of Chloroquine diphosphate?

Chloroquine phosphate is used for the treatment of chloroquine-sensitive P. falciparum, P. interna and P. tris. It is also used for the suppressive prophylaxis of malaria symptoms. It is also used in the treatment of parenteral amebiasis, connective tissue disease and photosensitivity disorders (e.g. solar erythema).

Conclusion

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