Chloroquine diphosphate CAS 50-63-5
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Chemical Name: Chloroquine diphosphate
CAS No.: 50-63-5
Molecular Fomula: C18H32ClN3O8P2
Chloroquine diphosphate: The Complete Guide
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Description of Chloroquine diphosphate
Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ.
Basic Info of Chloroquine diphosphate
1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, phosphate (1:2);alermine;7-Chloro-4-[4-(diethylamino)-1-methylbutylamino]quinoline Diphosphate;alermine;N4-(7-Chloro-4-quinolyl)-N1,N1-diethyl-1,4-pentanediamine Diphosphate;
Appearance & Physical State
460.6ºC at 760 mmHg
Desiccate at RT
What is Chloroquine diphosphate?
With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is alermine which has developed particularly rapidly in recent years. Do you know about alermine?
The official answer:alermine is a 4-aminoquinoline antimalarial drug, which can inhibit the nucleic acid synthesis of Plasmodium cleavage and interfere with the growth and reproduction of Plasmodium, and is highly effective in killing Plasmodium intraerythrocytic cleavage. alermine binds strongly to nucleoproteins by the proximity of the negatively charged 7-chloro group on its quinoline ring to the 2-amino group on the guanine of DNA, allowing the insertion of chloroquine between the two strands of the double helix of DNA. It forms a complex with DNA, thus preventing the replication of DNA and the transcription of RNA.
What’s the application of Chloroquine diphosphate?
Chloroquine phosphate is used for the treatment of chloroquine-sensitive P. falciparum, P. interna and P. tris. It is also used for the suppressive prophylaxis of malaria symptoms. It is also used in the treatment of parenteral amebiasis, connective tissue disease and photosensitivity disorders (e.g. solar erythema).
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