Dapoxetine hydrochlorideCAS# 129938-20-1
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Chemical Name: Dapoxetine hydrochloride
CAS No.: 129938-20-1
Molecular Formula C21H24ClNO
Monoisotopic mass 341.8744
Appearance: Shape powder color white
Sample: Available
Dapoxetine hydrochloride: The Complete Guide
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Description of Dapoxetine hydrochloride
Dapoxetine, marketed as Priligy and Westoxetin, among and other brands, is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18–64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.
Originally created by Eli Lilly pharmaceutical company, dapoxetine was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the Food and Drug Administration (FDA) for the treatment of PE in 2004. Dapoxetine has been sold in several European and Asian countries, and lately in Mexico. In the US, dapoxetine has been stuck in phase III development since 2003. However, it is expected to be marketed soon. In 2012, Menarini acquired the rights to commercialise Priligy in Europe, most of Asia, Africa, Latin America and the Middle East.
Basic Info of Dapoxetine hydrochloride
Chemical Name | Dapoxetine Hydrochloride |
|---|---|
Synonyms | (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine,hydrochloride;(S)-N,N-Dimethyl-α-[2-(1-naphthyloxy)ethyl]benzylamine Hydrochloride;(S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenylpropylamine Hydrochloride;Dapoxetine HCl;(S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride; |
CAS No. | 129938-20-1 |
Molecular Formula | C21H24ClNO |
Molecular Weight | 341.87400 |
PSA | 12.47000 |
LogP | 5.71360 |
Safety Info
HS Code | 2922199090 |
|---|---|
Symbol | GHS07 |
Caution Statement | P305 + P351 + P338 |
Signal Word | Warning |
Hazard Declaration | H302; H319; H413 |
Properties
Appearance & Physical State | White to off-white crystalline solid |
|---|---|
Boiling Point | 454.4ºC at 760 mmHg |
Melting Point | 175-179ºC |
Flash Point | 132.6ºC |
Vapor Pressure | 1.27E-09mmHg at 25°C |
Numbering system
| MDL number | MFCD08272809 |
|---|
What is Dapoxetine hydrochloride ?
With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Ambroxan which has developed particularly rapidly in recent years. Do you know about Ambroxan?
The official answer: Dapoxetine hydrochloride tablets are indicated for the treatment of men aged 18 to 64 years with premature ejaculation (PE) who experience persistent or recurrent ejaculation before, during, or shortly after vaginal penetration and before sexual satisfaction due to minimal sexual stimulation; and significant personal distress or interpersonal difficulties due to premature ejaculation (PE); and poor ejaculatory control.
What’s the application of Dapoxetine hydrochloride ?
Dapoxetine hydrochloride is a selective 5-hydroxytryptamine reuptake inhibitor (SSRI). Applications Dapoxetine impurities are organic synthesis intermediates and pharmaceutical intermediates that can be used in laboratory research and development processes and in chemical and pharmaceutical synthesis processes, mainly as intermediates of the API dapoxetine hydrochloride.
Conclusion
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