Denosumab CAS 615258-40-7
Denosumab , Promotion Season Now in Store and Free Sample for Testing with Factory Price
Chemical Name: Denosumab
CAS No.: 615258-40-7
Molecular Fomula: C6404H9912N1724O2004S50
Denosumab : The Complete Guide
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Description of Denosumab
D03684(AZD6244) is a drug that was discovered by Array BioPharma and was licensed to AstraZeneca. It is being investigated for the treatment of various types of cancer, such as non-small cell lung cancer (NSCLC).
Basic Info of Denosumab
What is Denosumab ?
With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is D03684 which has developed particularly rapidly in recent years. Do you know about D03684?
The official answer:D03684 is the first monoclonal antibody approved to specifically target the RANK ligand, a transmembrane or soluble protein required for osteoclasts to maintain their structure, function and survival. Human RANKL mRNA is mainly found in bone, bone marrow and lymphoid tissue. In bone, its main role is to stimulate osteoclast differentiation and activity and to inhibit osteoclast apoptosis. Osteoclasts are responsible for bone resorption and the presence of low levels of macrophage colony-stimulating factor and RANKL is necessary for the differentiation of osteoclast precursors into mature osteoclasts.
What’s the application of Denosumab ?
D03684 has a high affinity for RANKL, prevents RANK ligands from activating RANK on the surface of osteoclasts, inhibits osteoclast activation and development, reduces bone resorption, increases bone density and bone strength in both cortical bone and bone trabeculae, promotes bone reconstruction, and reduces the incidence of vertebral, non-vertebral and hip fractures in postmenopausal women with osteoporosis. The effect of D03684 on bone remodelling can be assessed by measuring a number of bone renewal markers, such as N-terminal peptide, a marker of bone resorption, and bone-specific alkaline phosphatase, a marker of bone formation.
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