Di-tert-butyl dicarbonate CAS 24424-99-5

Di-tert-butyl dicarbonate, Promotion Season Now in Store and Free Sample for Testing with Factory Price

Chemical Name: Di-tert-butyl dicarbonate
CAS No.: 24424-99-5
Molecular Fomula: C10H18O5
Molecular weight: 218.25
Appearance: White Low Melting Crystalline Solid
Sample: Available

Di-tert-butyl dicarbonate CAS# 24424-99-5

Description of Di-tert-butyl dicarbonate

Di-tert-butyl dicarbonate is a reagent widely used in organic synthesis. This carbonate ester reacts with amines to give N-tert-butoxycarbonyl or so-called Boc derivatives. These derivatives do not behave as amines, which allows certain subsequent transformations to occur that would have otherwise affected the amine functional group. The Boc can later be removed from the amine using acids. Thus, Boc serves as a protective group, for instance in solid phase peptide synthesis. It is unreactive to most bases and nucleophiles, allowing for an orthogonal Fluorenylmethyloxycarbonyl chloride (FMOC-Cl) protection.

Basic Info of Di-tert-butyl dicarbonate

Chemical Name

tert-butoxycarbonyl anhydride


DBDC;DIBOC,BOC;Dibutyldicarbonate;Pyrocarbonic Acid Di-tert-butyl Ester;Di-tert-butyl Pyrocarbonate;



Molecular Formula


Molecular Weight






Safety Info



Hazard Class


Safety Statements

S16; S26; S28

HS Code


WGK Germany


Packing Group



UN 2929 6.1/PG 1

Risk Statements

R11; R19; R26; R36/37/38; R43; R10

Hazard Codes

T+; Xi; F+

Hazard Declaration

H225; H315; H317; H318; H330; H335; H336

Caution Statement

P210; P280; P304 + P340 + P310; P305 + P351 + P338 + P310; P370 + P378; P403 + P235


GHS02, GHS05, GHS06

Signal Word



Appearance & Physical State

White to off-white microcrystalline powder


0.95 g/mL at 25 °C(lit.)

Boiling Point

65-67 °C

Melting Point

23 °C(lit.)

Flash Point

99 °F

Refractive Index

n20/D 1.409(lit.)

Storage Condition


Numbering system

MDL number


EINECS number


BRN number


RTECS number


PubChem number


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What is Di-tert-butyl dicarbonate?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Di-tert-butyl dicarbonate which has developed particularly rapidly in recent years. Do you know about Di-tert-butyl dicarbonate?

The official answer:Di-tert-butyl dicarbonate (Boc acid anhydride) is used in organic synthesis to introduce tert-butoxycarbonyl protection genes, especially for the amino protection of amino acids. It is widely used in the synthesis of pharmaceuticals, protein and peptide synthesis, biochemical foods, cosmetics and many other products.Amino acid BOC reagent. Used in organic synthesis to introduce tert-butoxycarbonyl (BOC) protecting groups, particularly suitable for the amino protection of amino acids.

What’s the application of Di-tert-butyl dicarbonate?

Used in organic synthesis to introduce tert-butoxycarbonyl protecting groups. Used as an intermediate in pharmaceutical and organic synthesis, it is an important amine protector amino acid BOC reagent applied in the synthesis of pharmaceutical and agrochemical products. Used in organic synthesis to introduce tert-butoxycarbonyl (BOC) protecting groups, particularly suitable for amino acid amino protection. Tri-Boc-protected hydrazines can be used in colouring reagents to prepare fluorenylmethoxycarbonyl esters to monitor solid phase aldehydes. Reagents for the preparation of tert-butoxycarbonyl-protected amines. Reagents for the introduction of tert-butoxycarbonyl-protected moieties. 


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Keywords of Di-tert-butyl dicarbonate

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