Diloxanide furoate CAS 3736-81-0
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Chemical Name: Diloxanide furoate
CAS No.: 3736-81-0
Molecular Fomula: C14H11Cl2NO4
Molecular weight:328.15
Appearance: White Solid
Sample: Available
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Description of Diloxanide furoate
Furoate(INN) is a luminal amebicide used in the treatment of amebiasis. It is formulated as the furoate ester diloxanide furoate. It is considered the luminal agent of choice for mild intestinal amebiasis or asymptomatic cyst carriers. It can also be added to metronidazole (active drug in luminal and extraintestinal amebiasis) in acute amebic dysentery as well as hepatic abscess(In hepatic abscess it is for the control of cysts in the lumen which may cause relapse). The drug was discovered by The Boots Company Plc in 1956 and introduced as Furamide. The Furamide brand is now owned by Abbott Laboratories. It is not available in the United States. In India it is available as Amicline by Franco-Indian.
Basic Info of Diloxanide furoate
| Chemical Name | [4-[(2,2-dichloroacetyl)-methylamino]phenyl] furan-2-carboxylate |
| Synonyms | Amebiazol; Histomibal;Furentomin;Diclofurazol;Entamide furoate; |
| CAS No. | 3736-81-0 |
| Molecular Formula | C14H11Cl2NO4 |
| Molecular Weight | 328.14700 |
| PSA | 59.75000 |
| LogP | 3.26530 |
Properties
Safety Statements | S36 |
Risk Statements | R22 |
Numbering system
UNII | YP4N72IW34 |
What is Diloxanide furoate?
- With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Diloxanide furoate which has developed particularly rapidly in recent years. Do you know about Diloxanide furoate?
- The official answer:Furoate is a prodrug of dibenzoxanide, a potent anti-protozoal agent with oral activity for studies related to amoebiasis, mild intestinal amoebiasis or asymptomatic encapsulated bacterial infections. Diloxanidefuroate(1.95-2.5g/ml)haspotentactivityagainstdifferentstrainsofE.histolytica,itisagainstBYso(grownwithbactChemicalbookeria),SFL3(grownwithChrithidiasp.),andSFL3(grownaxenically)with MICvaluesof2.5μg/ml,2.5μg/mland1.95g/ml, respectively. Diclofenac furoate, which kills amoebas directly, is effective against both intestinal and extra-intestinal amoebas and can be used in combination with emetine or chloroquine.
What’s the application of Diloxanide furoate?
It kills amoebas directly and is effective against both intestinal and extra-intestinal amoebas and can be used in combination with emetine or chloroquine. It is the drug of choice for the treatment of asymptomatic individuals with amoebic encapsulation.Abdominal distention is most common. Occasional nausea, vomiting, abdominal pain, oesophagitis, persistent diarrhoea, pruritus, urticaria, proteinuria and a vague feeling of paresthesia which disappears on completion of treatment.
Conclusion
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