Gliclazide CAS 21187-98-4

Products Name

Gliclazide

Gliclazide Details
CAS No.:21187-98-4

Other Names:Gliclazide

MF:C15H21N3O3S

EINECS No.:244-260-5

Purity:99

Model Number:TYA-022

Application:Material Intermediates

Appearance:white powder

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Gliclazide Properties Category  Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard Shelf life 2 years  Storage  should be stored in a well-closed container at low temperature, keep away from moisture, heat and light. Test Item Standard: USP Identification IR spectrum similar to that of RS HPLC retention time similar to that of RS Related substance Total impurities: NMT0.3% Single impurity: NMT0.1% Heavy metals NMT 10ppm Loss on drying NMT0.5% Residue on ignition NMT0.1% Assay 98.5%-101.0% Gliclazide Application liclazide is an oral antihyperglycemic agent used for the treatment of diabetes mellitus type II. It belongs to the sulfonylurea class of insulin secretagogues, which stimulates β cells of the pancreas to release insulin. Gliclazide binds to the β cell sulfonyl urea receptor (SUR1), further blocking the ATP sensitive potassium channels. Therefore, the potassium efflux substantially decreases, causing depolarization of the β cells. Then the voltage-dependent calcium channels in the β cell are open, resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules. Recent studies have also shown that gliclazide can effectiveimprove anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes and protect pancreatic beta-cells from damage by hydrogen peroxide. Gliclazide Packaging and Shipping Packaging:Packing: Net each in 25kg or 1000kg plastic woven bag, lined with PE bag. Shipping:It can be according to the customer’s request Gliclazide Storage Room temperature

Gliclazide CAS 21187-98-4

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Chemical Name: Gliclazide

CAS No.: 21187-98-4

Molecular Fomula: C15H21N3O3S

Molecular weight: 323.41

Appearance: white powder

Sample: Available

Gliclazide CAS 21187-98-4

Description of Gliclazide

Gliclazide is an oral hypoglycemic (anti-diabetic drug) and is classified as a sulfonylurea. Its classification has been ambiguous, as literature uses it as both a first-generation and second-generation sulfonylurea. Gliclazide was shown to protect human pancreatic beta-cells from hyperglycemia-induced apoptosis. It was also shown to have an antiatherogenic effect (preventing accumulation of fat in arteries) in type 2 diabetes.
It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.

Basic Info of Gliclazide

Chemical Name

gliclazide

Synonyms

Glyzide;Diaprel;DIAMICRON;GLIMICRON;1-[3-Azabicyclo[3.3.0]oct-3-yl]-3-p-toluenesulfonylurea;Expand

CAS No.

21187-98-4

Molecular Formula

C15H21N3O3S

Molecular Weight

323.41100

PSA

86.89000

LogP

3.43030

Safety Info

RTECS

YT4500000

Safety Statements

S25; S26; S36/37; S53

HS Code

2935009090

WGK Germany

2

Risk Statements

R21

Hazard Codes

Xn; Xi

Properties

Appearance & Physical State

white powder

Density

1.35 g/cm3

Melting Point

163-169ºC

Refractive Index

1.623

Stability

Stable at normal temperatures and pressures. Heat.

Storage Condition

Keep tightly closed.

Numbering system

PubChem number

24895090

RTECS number

YT4500000

EINECS number

244-260-5

MDL number

MFCD00409893

 
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What is Gliclazide?

With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Gliclazide which has developed particularly rapidly in recent years. Do you know about Gliclazide?

 

The official answer:Gliclazide, with the molecular formula C15H21N3O3S, is a sulfonylurea oral antidiabetic drug. It is a white crystalline or crystalline powder, odourless and tasteless. It is soluble in trichloromethane, slightly soluble in methanol, slightly soluble in ethanol and insoluble in water.

What’s the application of Gliclazide?

For adults with type 2 diabetes, diabetes mellitus with obesity or with vascular disease.

Conclusion

Sincere to the customer and in good faith of quality is our forever followed motto. It’s the basement to be a human and do business. We take all responsibility for our products and service sincerely. We are a company integrating R&D, production, and sales. The design, research, and development of pharmaceutical intermediates include more than 330 kinds of pharmaceutical intermediates such as Anti-infectives, Cardiovascular and Cerebrovascular Systems, Digestive systems, Santi-tumor, Nervous systems, Geriatric Drugs, and Gynecological Drugs. At the same time, we have more than 4,000 factories in strategic cooperation with nearly 50,000 chemical products, so we can provide you with a one-stop purchasing service, which greatly saves customers’ procurement costs and time.

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