Rolipram CAS 61413-54-5
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Chemical Name: Rolipram
CAS No.: 61413-54-5
Molecular Fomula: C16H21NO3
Molecular weight: 275.34
Appearance: white to off-white solid
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Description of Rolipram
Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It served as a prototype molecule for several companies’ drug discovery and development efforts.:668ff Rolipram was discontinued after clinical trials showed that its therapeutic window was too narrow; it could not be dosed at high enough levels to be effective without causing significant gastrointestinal side effects.:668; Rolipram has several activities that make it a continuing focus for research. The etiology of many neurodegenerative diseases involves misfolded and clumped proteins which accumulate in the brain. Cells have a mechanism to dispose of such proteins called the proteasome. However, in Alzheimer’s disease and some other conditions the activity of these proteasomes is impaired leading to a buildup of toxic aggregates. Research in mice suggests that rolipram has the ability to ramp up the activity of proteasomes and reduce the burden of these aggregates. Preliminary evidence suggests that this can improve spatial memory in mice engineered to have aggregate build-up. It continues to be used in research as a well-characterized PDE4 inhibitor.:669 It has been used in studies to understand whether PDE4 inhibition could be useful in autoimmune diseases, Alzheimer’s disease, cognitive enhancement, spinal cord injury, and respiratory diseases like asthma and COPD.
Basic Info of Rolipram
Appearance & Physical State
472.7ºC at 760 mmHg
What is Rolipram ?
With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Rolipram which has developed particularly rapidly in recent years. Do you know about Rolipram?
The official answer: Rolipram is an organic compound with a molecular weight of 275.34 and a molecular formula of C16H21NO3.
What’s the application of Rolipram ?
A selective inhibitor of PDE4, Rolipram (ZK-62711, SB 95952), inhibits the activity of immunopurified PDE4B and PDE4D with IC50s of 130 nM and 240 nM, . has anti-inflammatory activity.
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