Tazarotene CAS# 118292-40-3
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Chemical Name: Tazarotene
CAS No.: 118292-40-3
Molecular Fomula: C21H21NO2S
Molecular weight: 351.46
Appearance: Morphological powder acidity coefficient (pKa) 0.04±0.29 (predicted value) Color white to very faint yellow
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Description of Tazarotene
Tazarotene (marketed as Tazorac, Avage, Zorac, and Fabior) is a third-generation prescription topical retinoid sold as a cream, gel, or foam. Tazarotene is a member of the acetylenic class of retinoids. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). It is commonly sold in two concentrations: 0.05% and 0.1%.
Basic Info of Tazarotene
Tazarotene;ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate;Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate;
Appearance & Physical State
499.8ºC at 760 mmHg
4.03E-10mmHg at 25°C
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The official answer: Tazarotene is the first receptor-selective, third-generation aromatic retinoid that binds to two retinoic acid receptors (RAR-β; RAR-γ), but not to retinoic acid X receptor (RXR). It is safe and effective for the treatment of psoriasis and acne, and is used in keratosis pilaris, follicular sebaceous gland disease, and pre-cancerous skin lesions, with promising clinical development applications.
What’s the application of Tazarotene?
Tazarotene is a third-generation retinoid dermatological drug, a vitamin A-like precursor drug for topical use in the skin, with effects such as regulating epidermal cell differentiation and proliferation, and is indicated for the treatment of plaque psoriasis vulgaris. Tazarotene cream can also be used to treat facial acne.
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