Trifluoroacetic acid CAS 76-05-1

CF3COOH , Promotion Season Now in Store and Free Sample for Testing with Factory Price

Chemical Name: Trifluoroacetic acid

CAS No.:76-05-1

Molecular Fomula:C2HF3O2

Molecular weight:114.02

Appearance:Colorless Liquid

Sample: Available

Trifluoroacetic acid CAS#76-05-1

Description of Trifluoroacetic acid

  • CF3COOHis an organofluorine compound with the chemical formula CF3CO2H. It is a colorless liquid with a sharp odor similar to vinegar, but stronger in acidity. TFA is an analogue of acetic acid with the three hydrogen atoms replaced by three fluorine atoms. 
  • The acidity of TFA is approximately 34,000 times stronger than that of acetic acid due to the electronegativity of the trifluoromethyl group. TFA is widely used in organic chemistry for various purposes.

Basic Info of Trifluoroacetic acid

Chemical Name

trifluoroacetic acid


TFA;tri-fluoro-acetic acid;PERFLUOROACETATE;Acetic acid, trifluoro-;TRIFLUOROACETATE;Expand



Molecular Formula


Molecular Weight






Safety Info



Hazard Class


Safety Statements


HS Code


WGK Germany


Packing Group



UN 2699

Risk Statements

R20; R35; R52/53

Hazard Codes



GHS05, GHS07

Signal Word


Hazard Declaration

H314; H332; H412

Caution Statement

P261; P273; P280; P303 + P361 + P353; P304 + P340 + P310; P305 + P351 + P338


Appearance & Physical State

clear liquid



Boiling Point


Melting Point


Flash Point


Refractive Index


Water Solubility



Stable. Incompatible with combustible material, strong bases, water, strong oxidizing agents. Non-combustible. Hygroscopic. May react violently with bases.

Storage Condition


Vapor Density

3.9 (vs air)

Vapor Pressure

97.5 mm Hg ( 20 °C)

Numbering system

MDL number


EINECS number


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What is Trifluoroacetic acid?

  • With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. 
  • One such product is CF3COOH which has developed particularly rapidly in recent years. Do you know about CF3COOH?
  • The official answer:CF3COOH, with the chemical formula CF3COOH and a molecular weight of 114.02, can dissolve proteins if used in combination with carbon disulphide. 
  • It is also an excellent solvent for organic reactions and gives results that are difficult to obtain in normal solvents, e.g. the pyridine ring is preferentially hydrogenated when quinoline is catalyzed in normal solvents, but the benzene ring is preferentially hydrogenated in trifluoroacetic acid.

What’s the application of Trifluoroacetic acid?

It is mainly used in the production of new pesticides, pharmaceuticals and dyestuffs, etc. It also has a large potential for application development in the fields of materials, solvents, etc. Trifluoroacetic acid is mainly used in the synthesis of a variety of herbicides containing trifluoromethyl and heterocyclic Chemicalbook, and can now synthesize a variety of new herbicides with pyridine and quinoline groups; as an extremely strong protonic acid, it is widely used as a catalyst for the alkylation of aromatic compounds, acylation, olefin polymerization and other reactions


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Keywords of Trifluoroacetic acid

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United Kingdom Giles
United Kingdom Giles
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Peter has been my partner for many years, we met at the Shanghai CPHI Fair in 2014, for the first time I didn't have much interest in Peter's products because our company had a stable supplier. Although we didn't work together, Peter would often send me important news and interesting trend information about the industry, so we became good friends, even though I didn't place any orders with him during this time, even if it was a sample order. In September 2016, our original supplier was unable to provide us with the quality and delivery guarantees we needed, so I first thought of Peter and his company. Until now, we have maintained a very good personal friendship in addition to a steady business relationship.
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In all my years of sourcing from China, I first time to found that working with Sincere Chemical was so good, they helped me with all the production and delivery as well as a lot of technical expertise, which saved me a lot of time. When I first approached Peter for a quotation for Optical Brightener, he made me a detailed quotation with not only prices but also foreign trade details, company profile, company strengths, R&D capabilities, production capacity, packaging methods, raw material control, environmental protection, and much more. This information was a very important reference for me in making purchasing decisions. Sincere Chemical is a trustworthy supplier and I believe our business will grow from strength to strength!
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Korea Kim
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Hi, I'm Kim, I'm Peter's partner and although I don't like him very much (because he never gives me more money for my prices, hahaha) I'm still willing to write him customer feedback. As an international buyer, I have to deal with a lot of things every day and my inbox is often full of development letters. It's a lot of junk and meaningless pleasantries, which I don't like that much, but Peter's emails always give me a better understanding of the product and the industry. I am also very pleased with his work ethic, and I am very happy with his work every time I work with him, not only in providing quotations but also in facilitating all the details of my work so that I can concentrate more on other things, so he is the best supplier for me. Although his prices are not the lowest among all suppliers, his products give me the greatest peace of mind.
USA Franklin
USA Franklin
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Canada Kate
Canada Kate
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I just got the product. The quality is awesome. I’m very happy. Hope to place soon a new order in your company. Also wish for our future business.
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Brazil Aline
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We are a pharmaceutical products manufacturer in Brazil. I’m happy to cooperate with Sincere Chemical especially cooperate with Peter. Peter is patient and friendly. I’m satisfied with his 24*7 hours service. We are not only cooperators but also best friends with each other.
Mexico Gonzalo
Mexico Gonzalo
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Great service and very supportive. This is my first order and I feel fortunate to be with Peter and his company. Product received was the right good quality product, so my review is more related with the quality, service and shipment. Thank you for sending. next time I will order again. Good supplier...

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