Vonoprazan Fumarate CAS# 1260141-27-2
Vonoprazan Fumarate , Promotion Season Now in Store and Free Sample for Testing with Factory Price
Chemical Name: Vonoprazan Fumarate
CAS No.: 1260141-27-2
Molecular Formula C21H20FN3O6S
Average mass 461.463 Da
Monoisotopic mass 461.105682 Da
Description of Vonoprazan Fumarate
Vnoprazan Fumarate, widely known by the brand name Ambroxan, is a naturally occurring terpenoid and one of the key constituents responsible for the odor of ambergris. It is an autoxidation product of ambrein.
Basic Info of Vonoprazan Fumarate
DMSO > 10 mM
What is Vnoprazan Fumarate?
With the progress of science and technology and the development of society, chemical products have invariably permeated our daily lives, in medicine, food, cosmetics, electronics, industry, and other areas, becoming an essential part of our lives. One such product is Ambroxan which has developed particularly rapidly in recent years. Do you know about Ambroxan?
The official answer: Vnoprazan Fumarate is a chemical compound with a relative molecular weight of 236.34.
What’s the application of Vonoprazan Fumarate?
It is a reversible proton pump inhibitor. When it enters the body, it stops the secretion of gastric acid by inhibiting the combination of K+ and H+-K+-ATPase (proton pump) in the last step of acid secretion in the gastric lining cells to achieve the effect of acid inhibition. secretion. Currently, proton pump inhibitors (PPIs) are widely prescribed for the first-line treatment of acid-related diseases in Japan. However, PPIs do not always provide sufficient efficacy, and also the effect of gastric acid secretion inhibition may vary from person to person due to a Chemicalbook protein CYP-2C19, which is involved in PPI metabolism and whose coding gene has genetic polymorphism in different individuals. TAK-438 is not predominantly metabolized by CYP2C19, and the inhibitory effect of TAK-438 on the proton pump does not require acid activation, as the drug enters the stomach at high concentrations, producing a maximal inhibitory effect at the first dose, which can last up to 24 h. TAK-438 is stable in acid, and fast-acting formulations are readily available, eliminating the need for optimized formulation design (e.g., enteric coating). The differences in the starting dose of efficacy are not significant across patients. Based on these advantages, TAK-438 is expected to be a new therapeutic agent to solve the current problems in the treatment of acid-related diseases.
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