voriconazole cas 137234-62-9

Chemical Name:Voriconazole
CAS No.: 137234-62-9
Molecular Formula: C16H14F3N5O
Molecular Weight: 349.31
Appearance:White or almost white powder

Description

VoriconazoleDetails
Chemical Name:Voriconazole
CAS No.: 137234-62-9
Molecular Formula: C16H14F3N5O
Molecular Weight: 349.31
MolecularStructure:

Appearance:White or almost white powder
VoriconazoleTypical Properties

Item
Specifications
Results

Appearance
White or almost white powder
Almost white power

Solubility
Very slightly soluble in water;freely soluble in acetone and in methylene chloride
Conform

Identification
A.Infrared Absorption spectrum is identical to that of Voriconazole reference standard
Conform

B.Enantiomeric purity Solution should be clear and colorless
Conform

Appearance of solution
Solution should be clear and colourless
Solution is clear and colourless

Water(KF)
Not more than 0.4%
<0.1%

Sulfated ash
Not more than 0.1%
<0.1%

Enantiomeric purity
Impurity D not more than 0.2%
0.01%

Impurity E
Not more than 0.10%
0.02%

Related compounds(HPLC)
Impurity A
Not more than 0.15%
<0.01%

ImpurityB
Not more than 0.15%
<0.01%

Impurity C
Not more than 0.15%
<0.01%

Unspecified impurities
Not more than0.10%
<0.01%

Total impurities
Not more than 0.5%
0.03%

Residual solvents(GC)
Ethanol
Not more than 5000ppm
<LOD(LOD=121ppm)

Acetone
Not more than 5000ppm
<LOD(LOD=15ppm)

Assay (HPLC)
97.5%-102.0% calculated on the anhydrous basis
99.9%

Bacterial endotoxins
Less than 0.2IU/mg
Conform

Conclusion
It conforms to all the requirements of EP9.0

VoriconazoleUsage
Voriconazole is a broad-spectrum triazole antifungal drug used primarily to treat progressive, potentially life-threatening infections in immunodeficient patients.
VoriconazolePackaging and Shipping
Packing: Foil bag , Net weight: 1kg per bag
VoriconazoleStorage
The warehouse is ventilated and dryat low temperatureawayfromfood

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